研究者総覧 - 和久田　浩一

ワクダ　ヒロカズ
和久田　浩一

所属大分大学医学部附属病院中診特診・総合臨床研究センター

職種准教授

論文
論文	Utilization of Healthy Volunteers in Oncology Drug Development in Japan: A 10‐Year Analysis of Approved Anticancer Agents (2014–2024) Clinical and Translational Science 2026/06
論文	Fixed Versus Lottery Incentives for Promoting Engagement With a Cadence-Based Smartphone App: Randomized Crossover Trial JMIR Formative Research 2026/05/27
論文	Utility of Modeling and Simulations in Drug Development: Contrasting Japan, US and UK Descriptions of PBPK Modeling from Package Inserts The AAPS Journal 28 (2),60-60頁 2026/02/10
論文	Forensic implications of ethyl glucuronide and ethyl sulfate pharmacokinetics in Japanese adults: the influence of dose, genetic polymorphisms, and habitual alcohol consumption. Forensic toxicology 44 (1),152-166頁 2025/11/27
論文	Clinacanthus nutans leaf extract prevents metabolic dysfunction-associated steatotic liver (MASL) to metabolic dysfunction-associated steatohepatitis (MASH) progression in western diet-fed C57BL/6 mice Pharmacia 72,1-12頁 2025/09/25
論文	Predicting activities of Clinacanthus nutans (Burm.f.) Lindau metabolites against molecular targets in metabolic dysfunction-associated steatotic liver disease Journal of Pharmacy & Pharmacognosy Research 13 (s1),S316-S332頁 2025/04/01
論文	Correction: Assessing Immunogenicity in Drug Reviews and Prescribing Information in Japan. The AAPS journal 27 (1),44-44頁 2025/02/12
論文	Cadence-Based Pedometer App With Financial Incentives to Enhance Moderate-to-Vigorous Physical Activity: Development and Single-Arm Feasibility Study. JMIR formative research 8,e56376 2024/10/24
論文	Assessing Immunogenicity in Drug Reviews and Prescribing Information in Japan. The AAPS journal 26 (6),109-109頁 2024/10/08
論文	Safety, pharmacokinetics, and pharmacodynamics of <scp>ART</scp>‐648, a <scp>PDE4</scp> inhibitor in healthy subjects: A randomized, placebo‐controlled phase I study Clinical and Translational Science 17 (10),e70024 2024/10/02
論文	Flecainide Toxicity From Clinical Pharmacology Perspectives. Cureus 16 (7),e65884 2024/07
論文	An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. The AAPS journal 26 (1),22-22頁 2024/01/30
論文	Creating an in vivo hypoxic environment by gas inhalation for the potential evaluation of new pulse oximeters Translational and Regulatory Sciences 5 (1),23-27頁 2023/04
論文	Association between psychomotor function and ALDH2 genotype after consuming barley shochu: A randomized crossover trial. Clinical and translational science 16 (4),686-693頁 2023/02/07
論文	Pharmacokinetics of lanoconazole in human skin after repeated topical application The Journal of Dermatology 2022/07/10
論文	Scientific misconduct in sponsored clinical trials in Japan: published cases are the “tip of the iceberg” Translational and Regulatory Sciences 4 (2),30-36頁 2022/06
論文	Possible Involvement of Muscarinic Receptor Blockade in Mirabegron Therapy for Patients with Overactive Bladder. The Journal of pharmacology and experimental therapeutics 377 (2),201-206頁 2021/05
論文	9,10-Phenanthrenequinone（PQ）を誘導体化試薬として用いたヒト血漿中アセトアルデヒド測定法の検討. 日本法科学技術学会誌 26 (2),173-182頁 2021
論文	No Effect of Digoxin on Rosuvastatin Pharmacokinetics in Healthy Subjects: Utility of Oita Combination for Clinical Drug-Drug Interaction Study. Clinical and translational science 12 (5),513-518頁 2019/09
論文	Effect of Royal Jelly on Mouse Isolated Ileum and Gastrointestinal Motility. Journal of medicinal food 22 (8),789-796頁 2019/08
論文	Histological evaluation of nintedanib in non-alcoholic steatohepatitis mice. Life sciences 228,251-257頁 2019/07/01
論文	Effects of Anticholinergic Drugs Used for the Therapy of Overactive Bladder on P-Glycoprotein Activity. Biological & pharmaceutical bulletin 42 (12),1996-2001頁 2019
論文	Effect of fermented buckwheat sprouts extract and its ingredients on rat bladder (ラット膀胱収縮能に対する発芽そば発酵エキスおよびその含有成分の影響) 日本排尿機能学会誌 29 (2),451-455頁 2018
論文	Age-related changes to vascular protease-activated receptor 2 in metabolic syndrome: a relationship between oxidative stress, receptor expression, and endothelium-dependent vasodilation CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 95 (4),356-364頁 2017/04
論文	Effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by a kappa-opioid antagonist, nor-BNI, in ICR mice IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 39 (5),292-295頁 2017
論文	Characterization of muscarinic receptor binding by the novel radioligand, [H-3]imidafenacin, in the bladder and other tissues of rats JOURNAL OF PHARMACOLOGICAL SCIENCES 131 (3),184-189頁 2016/07
論文	Functional Relationship between Arterial Tissue and Perivascular Adipose Tissue in Metabolic Syndrome YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 136 (5),693-697頁 2016/05
論文	Panax notoginseng saponins ameliorate impaired arterial vasodilation in SHRSP.Z-Leprfa/lzmDmcr rats with metabolic syndrome Clinical and Experimental Pharmacology and Physiology 43 (4),459-467頁 2016/04/01
論文	A maternal high salt diet disturbs cardiac and vascular function of offspring LIFE SCIENCES 136,42-51頁 2015/09
論文	Differential effects of mitogen-activated protein kinase pathway inhibitors on P-glycoprotein activation ADMET and DMPK 3 (1),77-83頁 2015/04
論文	Enhanced Nitric Oxide Synthase Activation via Protease-Activated Receptor 2 Is Involved in the Preserved Vasodilation in Aortas from Metabolic Syndrome Rats JOURNAL OF VASCULAR RESEARCH 52 (4),232-243頁 2015
論文	Is Hyperuricemia a Risk Factor for Arteriosclerosis? Uric Acid and Arteriosclerosis in Apolipoprotein E-Deficient Mice BIOLOGICAL & PHARMACEUTICAL BULLETIN 37 (12),1866-1871頁 2014/12
論文	Disturbance of vasodilation via protease-activated receptor 2 in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome VASCULAR PHARMACOLOGY 63 (1),46-54頁 2014/10
論文	ATPを介したクロストーク. 日本薬理学雑誌 143 (6),283-288頁 2014/06
論文	Chronic oxidative-nitrosative stress impairs coronary vasodilation in metabolic syndrome model rats MICROVASCULAR RESEARCH 88,70-78頁 2013/07
論文	Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 91 (2),124-133頁 2013/02
論文	Determination of the Effects of Green Tea Extract and Fruit Extracts on P-glycoprotein Activity in Caco-2 Cells by Using a New Method Involving Confocal Laser Scanning Microscopy. Pharmacometrics 84 (1/2),7-12頁 2013/02
論文	Effects of telmisartan on arterial vasodilation via protease-activated receptor-2 activation in SHRSP.Z-Leprfa/IzmDmcr rats with metabolic syndrome CORONARY ARTERY DISEASE 2013,139-142頁 2013
論文	新聞の折り込み広告における健康食品の流行の推移とその科学的根拠. New Diet Therapy 27 (4),3-10頁 2012/03
論文	Effects of functional food constituents on P-glycoprotein activity in Caco-2 cells determined by a new method using confocal laser scanning microscopy. Pharmacometrics 81 (3/4),35-40頁 2011/12
論文	A novel method using confocal laser scanning microscopy for sensitive measurement of P-glycoprotein-mediated transport activity in Caco-2 cells JOURNAL OF PHARMACY AND PHARMACOLOGY 63 (8),1015-1021頁 2011/08
論文	低酸素による血管・心臓交感神経からのノルアドレナリン遊離に対するニコランジルの影響. Therapeutic Research 32 (2),279-282頁 2011
論文	Highly Sensitive Measurement of P-Glycoprotein-Mediated Transport Activity in Caco-2 Cells BIOLOGICAL & PHARMACEUTICAL BULLETIN 33 (7),1238-1241頁 2010/07
論文	リアルタイムライブセルイメージングを応用したサプリメント・医薬品相互作用の高感度評価法の開発と展望. New Diet Therapy 26 (1),11-16頁 2010/06