研究者総覧 - 上村　尚人

ウエムラ　ナオト
上村　尚人

所属大分大学医学部臨床医学・臨床薬理学

職種教授

論文
論文	Fixed Versus Lottery Incentives for Promoting Engagement With a Cadence-Based Smartphone App: Randomized Crossover Trial JMIR Formative Research 10,e86189-e86189頁 2026/05/27
論文	Utility of Modeling and Simulations in Drug Development: Contrasting Japan, US and UK Descriptions of PBPK Modeling from Package Inserts. The AAPS journal 28 (2),60-60頁 2026/02/10
論文	Water intake during drinking does not alleviate hangover symptoms. Frontiers in pharmacology 17,1852528-1852528頁 2026
論文	Forensic implications of ethyl glucuronide and ethyl sulfate pharmacokinetics in Japanese adults: the influence of dose, genetic polymorphisms, and habitual alcohol consumption. Forensic toxicology 2025/11/27
論文	Clinacanthus nutans leaf extract prevents metabolic dysfunction-associated steatotic liver (MASL) to metabolic dysfunction-associated steatohepatitis (MASH) progression in western diet-fed C57BL/6 mice Pharmacia 72,1-12頁 2025/09/25
論文	Acetyl-CoA Carboxylase Inhibitors for Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pharmaceuticals (Basel, Switzerland) 18 (9) 2025/08/27
論文	Correction: Assessing Immunogenicity in Drug Reviews and Prescribing Information in Japan. The AAPS journal 27 (1),44-44頁 2025/02/12
論文	A phase 2 randomized, double-blind trial of ART-001, a selective PI3Kα inhibitor, for the treatment of slow-flow vascular malformations. Orphanet journal of rare diseases 20 (1),64-64頁 2025/02/10
論文	Cadence-Based Pedometer App With Financial Incentives to Enhance Moderate-to-Vigorous Physical Activity: Development and Single-Arm Feasibility Study. JMIR formative research 8,e56376 2024/10/24
論文	Assessing Immunogenicity in Drug Reviews and Prescribing Information in Japan. The AAPS journal 26 (6),109-109頁 2024/10/08
論文	Safety, pharmacokinetics, and pharmacodynamics of ART-648, a PDE4 inhibitor in healthy subjects: A randomized, placebo-controlled phase I study. Clinical and translational science 17 (10),e70024 2024/10
論文	Flecainide Toxicity From Clinical Pharmacology Perspectives. Cureus 16 (7),e65884 2024/07
論文	The Prospective Natural History Study of Patients with Intractable Venous Malformation and Klippel-Trenaunay Syndrome to Guide Designing a Proof-of-Concept Clinical Trial for Novel Therapeutic Intervention. Lymphatic research and biology 22 (1),27-36頁 2024/02
論文	An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. The AAPS journal 26 (1),22-22頁 2024/01/30
論文	臨床薬理学教育におけるポリファーマシーに関する症例を活用した医療面接実習教育効果の探索的検討日本臨床薬理学会学術総会抄録集 44回,2-F3頁 2024/01
論文	QbDにおけるコミュニケーションとIQRMPの検討日本臨床薬理学会学術総会抄録集 45回,np533-np534頁 2024
論文	臨床薬理学教育においてポリファーマシーに関する症例シナリオを導入した医療面接実習の有用性学生及び教員の双方向からの検討日本臨床薬理学会学術総会抄録集 45回,np283-np284頁 2024
論文	A Heart Failure Smartphone Application That Nudges Patients/Physicians Toward Optimal Medical Therapy - Development and Usability Study. Circulation reports 5 (12),459-462頁 2023/12/08
論文	A randomized, placebo-controlled study to evaluate safety and pharmacokinetics of ART-001 with a novel oral pediatric formulation in healthy subjects. Clinical and translational science 16 (10),1898-1910頁 2023/10
論文	Association between psychomotor function and ALDH2 genotype after consuming barley shochu: A randomized crossover trial. Clinical and translational science 16 (4),686-693頁 2023/04
論文	Creating an in vivo hypoxic environment by gas inhalation for the potential evaluation of new pulse oximeters Translational and Regulatory Sciences 5 (1),23-27頁 2023/04
論文	Antibody Avidity Maturation Following Recovery From Infection or the Booster Vaccination Grants Breadth of SARS-CoV-2 Neutralizing Capacity. The Journal of infectious diseases 227 (6),780-787頁 2023/03/28
論文	Correction: A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study). BMC medicine 20 (1),478-478頁 2022/12/08
論文	A phase I, randomized, placebo-controlled study of molnupiravir in healthy Japanese to support special approval in Japan to treat COVID-19. Clinical and translational science 15 (11),2697-2708頁 2022/11
論文	Cumulative seroprevalence among healthcare workers after the first wave of the COVID-19 pandemic in El Salvador, Central America. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 28 (11),1508-1510頁 2022/11
論文	Pharmacokinetics of lanoconazole in human skin after repeated topical application. The Journal of dermatology 49 (11),1118-1123頁 2022/11
論文	A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study). BMC medicine 20 (1),342-342頁 2022/09/27
論文	A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody MK-1654 in healthy Japanese adults. Clinical and translational science 15 (7),1753-1763頁 2022/07
論文	Scientific misconduct in sponsored clinical trials in Japan: published cases are the “tip of the iceberg” Translational and Regulatory Sciences 4 (2),30-36頁 2022/06
論文	A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19. Clinical and translational science 14 (5),1967-1976頁 2021/09
論文	Performance Index for Types of Clinical Research Support Service Providers for Academic Research Organizations in Japan: A Cross-Sectional Survey. Clinical and translational science 14 (2),745-755頁 2021/03
論文	The μ-opioid receptor gene polymorphism 118A>G weakens the pharmacological action of buprenorphine. International journal of clinical pharmacology and therapeutics 58 (11),626-633頁 2020/11
論文	Advanced Medical Care Program for the Rapid Introduction of Healthcare Technologies to the National Health Insurance System in Japan. Clinical and translational science 13 (4),700-706頁 2020/07
論文	Discrepancy Between Fasting Flow-Mediated Dilation and Parameter of Lipids in Blood: A Randomized Exploratory Study of the Effect of Omega-3 Fatty Acid Ethyl Esters on Vascular Endothelial Function in Patients With Hyperlipidemia. Advances in therapy 37 (5),2169-2183頁 2020/05
論文	β-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis. Scientific reports 9 (1),20056-20056頁 2019/12/27
論文	Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis. Annals of dermatology 31 (6),631-639頁 2019/12
論文	アフリカトリパノソーマ症治療薬開発に向けた、First in Human試験の立案・実施への取り組み臨床薬理 50 (Suppl.),S258-S258頁 2019/11
論文	グローバルヘルス課題克服にむけたコンゴ民主共和国におけるトランスレーショナルリサーチ拠点の形成臨床薬理 50 (Suppl.),S258-S258頁 2019/11
論文	Development of a simultaneous quantitation for short-, medium-, long-, and very long-chain fatty acids in human plasma by 2-nitrophenylhydrazine-derivatization and liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 1126-1127,121771-121771頁 2019/09/15
論文	No Effect of Digoxin on Rosuvastatin Pharmacokinetics in Healthy Subjects: Utility of Oita Combination for Clinical Drug-Drug Interaction Study. Clinical and translational science 12 (5),513-518頁 2019/09
論文	構造生物学から観た寄生適応の分子戦略メタボローム解析による薬剤標的の評価とアフリカトリパノソーマ症に対する早期臨床開発日本生化学会大会プログラム・講演要旨集 92回,[2S06m-05]頁 2019/09
論文	Histological evaluation of nintedanib in non-alcoholic steatohepatitis mice. Life sciences 228,251-257頁 2019/07/01
論文	Application of Physiologically Based Pharmacokinetic Modeling to Predict Pharmacokinetics in Healthy Japanese Subjects. Clinical pharmacology and therapeutics 105 (4),1018-1030頁 2019/04
論文	From Molecule to Patient: Building Bridges Not Walls with Clinical Pharmacology and Translational Medicine. Clinical and translational science 12 (2),84-84頁 2019/03
論文	Effects of Anticholinergic Drugs Used for the Therapy of Overactive Bladder on P-Glycoprotein Activity. Biological & pharmaceutical bulletin 42 (12),1996-2001頁 2019
論文	Effects of uric acid on vascular endothelial function from bedside to bench. Hypertension research : official journal of the Japanese Society of Hypertension 41 (11),923-931頁 2018/11
論文	Clinical Drug-Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects. Clinical and translational science 11 (5),477-486頁 2018/09
論文	Effect of Hepatic Impairment on the Pharmacokinetics of Grazoprevir, a Hepatitis C Virus Protease Inhibitor. Antimicrobial agents and chemotherapy 61 (12) 2017/12
論文	Effects of the orexin receptor antagonist suvorexant on respiration during sleep in healthy subjects. Journal of clinical pharmacology 55 (10),1093-100頁 2015/10
論文	Plasma capric acid concentrations in healthy subjects determined by high-performance liquid chromatography. Annals of clinical biochemistry 52 (Pt 5),588-96頁 2015/09
論文	Use of minipig skin biopsy model as an innovative tool to design topical formulation to achieve desired pharmacokinetics in humans. Journal of pharmaceutical sciences 104 (5),1701-8頁 2015/05
論文	Gly143Glu polymorphism of the human carboxylesterase1 gene in an Asian population. European journal of clinical pharmacology 69 (3),735-6頁 2013/03
論文	The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans. European journal of clinical pharmacology 69 (1),21-30頁 2013/01
論文	Reliability and feasibility of methods to quantitatively assess peripheral edema. Clinical medicine & research 7 (1-2),21-31頁 2009/06
論文	Human pharmacology of the methamphetamine stereoisomers. Clinical pharmacology and therapeutics 80 (4),403-20頁 2006/10
論文	Bioequivalence and rapid absorption of zolmitriptan nasal spray compared with oral tablets in healthy Japanese subjects. Clinical drug investigation 25 (3),199-208頁 2005
論文	Cocaine levels in sweat collection patches vary by location of patch placement and decline over time. Journal of analytical toxicology 28 (4),253-9頁 2004
論文	Pharmacokinetic and pharmacodynamic differences between ocular and nasal instillation of carteolol on intraocular pressure and heart rate in Japanese men with high CYP2D6 activity. Journal of clinical pharmacology 42 (9),1020-6頁 2002/09
論文	Disposition of cocaine in skin, interstitial fluid, sebum, and stratum corneum. Journal of analytical toxicology 26 (8),547-53頁 2002