研究者総覧 - 塚本　善之

ツカモト　ヨシユキ
塚本　善之

所属大分大学医学部基礎医学・分子病理学

職種講師

論文
論文	The SMYD3-MEK/ERK Axis Contributes to Intestinal Metaplasia and H. pylori-associated Gastric Carcinogenesis. Laboratory investigation; a journal of technical methods and pathology,106137-106137頁 2026/05/20
論文	Annexin A8 drives MEK inhibitor resistance, providing a druggable target for pancreatic ductal adenocarcinoma. Molecular cancer therapeutics 2026/01/29
論文	Establishment of a novel organoid line from esophageal squamous cell carcinoma with cytoplasmic vacuoles: Association of autolysosome swelling with vacuole formation Pathobiology Accepted 2025/11/07
論文	MAPK阻害薬抵抗性関連分子ANXA8を標的とした膵癌の新規治療法の開発(Development of a novel therapeutic strategy for pancreatic cancer targeting ANXA8) 日本癌学会総会記事 83回,P-2302頁 2024/09
論文	Disulfidptosis: A Novel Prognostic Criterion and Potential Treatment Strategy for Diffuse Large B-Cell Lymphoma (DLBCL). International journal of molecular sciences 25 (13) 2024/06/28
論文	VSNL1は大腸癌の発症・進展過程で細胞増殖能の亢進に寄与する(VSNL1 contributes to cell proliferation in colorectal carcinogenesis) 日本病理学会会誌 113 (1),310-310頁 2024/02
論文	胆汁酸はERKシグナル伝達経路を介し化生変化を誘導する日本胃癌学会総会記事 96回,377-377頁 2024/02
論文	胆汁酸はERKシグナル伝達経路を介し化生変化を誘導する日本胃癌学会総会記事 96回,377-377頁 2024/02
論文	IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors Frontiers in Oncology 13 2024/01/24
論文	Characterization of residual cancer by comparison of a pair of organoids established from a patient with esophageal squamous cell carcinoma before and after neoadjuvant chemotherapy Human Cell 2024/01
論文	Association of immune-related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma. Cancer science 114 (11),4459-4474頁 2023/11
論文	Overexpression of VSNL1 enhances cell proliferation in colorectal carcinogenesis. Pathobiology : journal of immunopathology, molecular and cellular biology 2023/10/05
論文	Clusterinは膵癌細胞のMAPキナーゼ不応性に関与する(Clusterin is involved in the refractory response of pancreatic cancer cells to a MAP kinase inhibitor) 日本癌学会総会記事 82回,423-423頁 2023/09
論文	膵癌においてANXA8はMAPK阻害薬耐性に関与する(ANXA8 is involved in the resistance to MAPK inhibitor in pancreatic cancer) 日本癌学会総会記事 82回,1921-1921頁 2023/09
論文	Patient-Derived Ex Vivo Cultures and Endpoint Assays with Surrogate Biomarkers in Functional Testing for Prediction of Therapeutic Response Cancers 15 (16),4104-4104頁 2023/08/15
論文	シスプラチン処理後のc-Junリン酸化亢進をバイオマーカーとした食道癌術前化学療法の効果予測日本病理学会会誌 112 (1),354-355頁 2023/03
論文	Efficient Establishment of Bile-Derived Organoids From Patients With Biliary Cancer. Laboratory investigation; a journal of technical methods and pathology 103 (6),100105-100105頁 2023/02/07
論文	Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor. Cancer science 114 (5),2189-2202頁 2023/01/24
論文	Potential association of eEF1A dimethylation at lysine 55 in the basal area of Helicobacter pylori-eradicated gastric mucosa with the risk of gastric cancer: a retrospective observational study. BMC gastroenterology 22 (1),490-490頁 2022/11/28
論文	IMiDs/CELMoDによるATL細胞の増殖抑制とその機序日本血液学会学術集会 84回,1215-1215頁 2022/10
論文	IMiDs/CELMoDによるATL細胞の増殖抑制とその機序日本血液学会学術集会 84回,1215-1215頁 2022/10
論文	Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids. Laboratory investigation; a journal of technical methods and pathology 102 (12),1355-1366頁 2022/08/03
論文	TAS-116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T-cell leukemia. Cancer science 113 (2),684-696頁 2022/02
論文	c-Junリン酸化亢進はシスプラチン感受性と相関する日本癌学会総会記事 80回,[P2-4]頁 2021/09
論文	Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential Pathobiology 88 (5),374-382頁 2021
論文	Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells Laboratory Investigation 101 (8),1036-1047頁 2021
論文	DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells Biochemical and Biophysical Research Communications 528 (3),586-593頁 2020/07
論文	A transgenic mouse expressing miR‐210 in proximal tubule cells shows mitochondrial alteration: possible association of miR‐210 with a shift in energy metabolism The Journal of Pathology 251 (1),12-25頁 2020/05
論文	Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan. Genome announcements 6 (25) 2018/06/21
論文	Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas. Cancer science 109 (1),250-258頁 2018/01
論文	A 17-molecule set as a predictor of complete response to neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil in esophageal cancer PLOS ONE 12 (11),e0188098 2017/11
論文	大腸癌におけるDUSP4発現低下は増殖能・浸潤能に関与する日本癌学会総会記事 76回,P-2033頁 2017/09
論文	Oncogene-inducible organoids as a miniature platform to assess cancer characteristics JOURNAL OF CELL BIOLOGY 216 (6),1505-1507頁 2017/06
論文	Decidualization Differentially Regulates microRNA Expression in Eutopic and Ectopic Endometrial Stromal Cells REPRODUCTIVE SCIENCES 24 (3),445-455頁 2017/03
論文	Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels DEVELOPMENT 144 (6),1107-1112頁 2017/03
論文	食道扁平上皮癌におけるCannabinoid receptor 1の発現亢進は転移と予後に相関する日本病理学会会誌 106 (1),375-376頁 2017/03
論文	Overexpression of cannabinoid receptor 1 in esophageal squamous cell carcinoma is correlated with metastasis to lymph nodes and distant organs, and poor prognosis PATHOLOGY INTERNATIONAL 67 (2),83-90頁 2017/02
論文	Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells. Cancer science 107 (12),1919-1928頁 2016/12
論文	DUSP4の発現低下は膵上皮内癌から浸潤癌への進展に関与する日本癌学会総会記事 75回,P-3006頁 2016/10
論文	Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K+ Channel, I-K.ACh CIRCULATION JOURNAL 80 (6),1346-+頁 2016/06
論文	Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma CANCER RESEARCH 76 (9),2612-2625頁 2016/05
論文	Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway JOURNAL OF PATHOLOGY 239 (1),97-108頁 2016/05
論文	Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma CANCER SCIENCE 107 (4),417-423頁 2016/04
論文	腎特異的ノックアウトマウスモデルにおいて、SAV1 lossはHippo pathwayの抑制により腎尿細管上皮細胞に過剰増殖をもたらす日本泌尿器科学会総会 104回,PP1-019頁 2016/04
論文	胃癌におけるNEK阻害剤への感受性予測因子の探索日本消化器病学会雑誌 113 (臨増総会),A230-A230頁 2016/03
論文	心房細動心筋におけるイオンチャネルリモデリングを制御するmicroRNA 日本生理学雑誌 77 (2),45-45頁 2015/03
論文	Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma CANCER MEDICINE 4 (1),112-124頁 2015/01
論文	Expression of DDX27 contributes to colony-forming ability of gastric cancer cells and correlates with poor prognosis in gastric cancer AMERICAN JOURNAL OF CANCER RESEARCH 5 (10),2998-3014頁 2015
論文	Helicobacter pylori Infection Introduces DNA Double-Strand Breaks in Host Cells INFECTION AND IMMUNITY 82 (10),4182-4189頁 2014/10
論文	ヒト腎細胞癌移植モデルにおいてSAV1は腫瘍増殖を抑制する(SAV1 inhibits renal tumor growth in xenograft model) 日本癌学会総会記事 73回,P-3215頁 2014/09
論文	The Vav3 oncogene enhances the malignant potential of prostate cancer cells under chronic hypoxia UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32 (2),101-109頁 2014/02
論文	Death receptor 6 is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989) 70 (6),485-96頁 2013/12
論文	ATL治療候補薬剤によるATL細胞内の転写プロファイルの変動(Dynamic gene expression alteration in ATL cells after the addition of newly developed anti-tumor chemicals) 日本癌学会総会記事 72回,489-489頁 2013/10
論文	CCAAT/Enhancer-Binding Protein alpha Is Epigenetically Silenced by Histone Deacetylation in Endometriosis and Promotes the Pathogenesis of Endometriosis JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98 (9),E1474-E1482頁 2013/09
論文	Commensal Microbiota Contributes to Chronic Endocarditis in TAX1BP1 Deficient Mice PLOS ONE 8 (9),e73205 2013/09
論文	MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2. Molecular cancer 12,15-15頁 2013/02/25
論文	Genomic Profiling of Oral Squamous Cell Carcinoma by Array-Based Comparative Genomic Hybridization PLOS ONE 8 (2),e56165 2013/02
論文	Genomic profiling of renal cell carcinoma in patients with end-stage renal disease CANCER SCIENCE 103 (3),569-576頁 2012/03
論文	Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma BMC CANCER 11,523 2011/12
論文	Aberrant DNA methylation status of endometriosis: Epigenetics as the pathogenesis, biomarker and therapeutic target JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 37 (7),683-695頁 2011/07
論文	Genomic Profiling of Submucosal-Invasive Gastric Cancer by Array-Based Comparative Genomic Hybridization PLOS ONE 6 (7),e22313 2011/07
論文	Overexpression of miR-210, a downstream target of HIF1, causes centrosome amplification in renal carcinoma cells. J Pathol 224 (2),280-288頁 2011/06
論文	Overexpression of miR-210, a downstream target of HIF1 alpha, causes centrosome amplification in renal carcinoma cells JOURNAL OF PATHOLOGY 224 (2),280-288頁 2011/06
論文	Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study BMC GASTROENTEROLOGY 10,114 2010/09
論文	Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population CLINICAL MICROBIOLOGY AND INFECTION 16 (8),1264-1269頁 2010/08
論文	Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam European Journal of Clinical Microbiology and Infectious Diseases 29 (6),651-660頁 2010/06
論文	Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization JOURNAL OF PATHOLOGY 221 (1),96-105頁 2010/05
論文	MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3 zeta CANCER RESEARCH 70 (6),2339-2349頁 2010/03
論文	Analysis of p53 Mutations and the Expression of p53 and p21(WAF1/CIP1) Protein in 15 Cases of Sebaceous Carcinoma of the Eyelid INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 51 (1),7-11頁 2010/01
論文	Evaluation of Rapid Urine Test for the Detection of Helicobacter pylori Infection in the Vietnamese Population DIGESTIVE DISEASES AND SCIENCES 55 (1),89-93頁 2010/01
論文	Induction of GNE in Myofibers after Muscle Injury PATHOBIOLOGY 77 (4),191-199頁 2010
論文	PP-085 ヒト外尿道括約筋および肛門挙筋におけるトランスクリプトーム解析(発表・討論,一般演題ポスター,第98回日本泌尿器科学総会) 日本泌尿器科学会雑誌 101 (2),390 2010
論文	Evaluation of the Anti-East Asian CagA-Specific Antibody for CagA Phenotyping CLINICAL AND VACCINE IMMUNOLOGY 16 (11),1687-1692頁 2009/11
論文	Genome-wide microRNA expression profiling in renal cell carcinoma: Significant down-regulation of miR-141 and miR-200c Journal of Pathology 216,418-427頁 2008/12/01
論文	Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas APMIS 116 (12),1097-1106頁 2008/12
論文	Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer JOURNAL OF PATHOLOGY 216 (4),471-482頁 2008/12
論文	Genome-wide microRNA expression profiling in renal cell carcinoma: significant downregulation of miR-141 and miR-200c. J Pathol. 216 (4),418-427頁 2008/12
論文	Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody PATHOLOGY INTERNATIONAL 58 (4),218-225頁 2008/04
論文	Phosphorylation status of epidermal growth factor receptor is closely associated with responsiveness to gefitinib in pulmonary adenocarcinoma HUMAN PATHOLOGY 39 (3),316-323頁 2008/03
論文	Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury HISTOCHEMISTRY AND CELL BIOLOGY 129 (1),55-64頁 2008/01
論文	High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma Journal of Pathology 213,392-401頁 2007/12/01
論文	Immunohistochemical diagnosis of the cagA-gene genotype of Helicobacter pylori with anti-East Asian CagA-specific antibody Cancer Science 98 (4),521-528頁 2007/04
論文	ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas MODERN PATHOLOGY 20 (2),199-207頁 2007/02
論文	Extracellular signal-regulated protein kinase is activated in cervical intraepithelial neoplasms but inactivated in invasive cervical carcinoma PATHOLOGY INTERNATIONAL 56 (7),368-374頁 2006/07
論文	Altered expression of ARPP protein in skeletal muscles of patients with muscular dystrophy, congenital myopathy and spinal muscular atrophy PATHOBIOLOGY 71 (1),43-51頁 2004
論文	Assignment of the murine ankyrin-repeated protein gene (Ankrd2) to mouse chromosome 19C3→D1 and rat chromosome 1q51→q53 by fluorescence in situ hybridization Cytogenetic and Genome Research 105 (1),159-A3頁 2004
論文	Cardiac-restricted ankyrin-repeated protein is differentially induced in duchenne and congenital muscular dystrophy LABORATORY INVESTIGATION 83 (5),711-719頁 2003/05
論文	Arpp, a new homolog of Carp, is preferentially expressed in type 1 skeletal muscle fibers and is markedly induced by denervation LABORATORY INVESTIGATION 82 (5),645-655頁 2002/05
論文	Carp, a cardiac ankyrin-repeated protein, and its new homologue, Arpp, are differentially expressed in heart, skeletal muscle, and rhabdomyosarcomas AMERICAN JOURNAL OF PATHOLOGY 160 (5),1767-1778頁 2002/05
論文	CARP, a putative genetic marker for cardiac hypertrophy,and its new homologue,Arpp, a differentially expressed in heart,skeletal muscle and Rhabdomyosarcoma American Journal of Pathology 160,1767-1778頁 2002
論文	Identification of a Novel Human Ankyrin-Repeated Protein Homologous to CARP. Biochemical and Biophysical Research Communications 285,715-723頁 2001