研究者総覧 - 内田　宅郎

ウチダ　タクロウ
内田　宅郎

所属大分大学グローカル感染症研究センター

職種講師

論文
論文	Prime editing enables isogenic modeling of PNPLA3-I148M-associated lipotoxicity in hepatocytes Molecular Therapy Nucleic Acids 2026/09
論文	IgA-Enriched Phenotype Predicts Liver-Related Events in MASLD. Journal of hepatology 2026/07/15
論文	The SMYD3-MEK/ERK Axis Contributes to Intestinal Metaplasia and H. pylori-associated Gastric Carcinogenesis. Laboratory investigation; a journal of technical methods and pathology,106137-106137頁 2026/05/20
論文	A Case of Obstructive Jaundice due to Bile Duct Tumor Thrombus of Hepatocellular Carcinoma Diagnosed by Peroral Cholangioscopy DEN Open 2026/04
論文	Efficacy of Endoscopic Ultrasound-guided Transluminal Drainage Using Lumen-apposing Metal Stents for the Treatment of Pancreatic Fluid Collections. DEN open 6 (1),e70249 2026/04
論文	Primary splenic angiosarcoma with diffuse intrasinusoidal hepatic metastasis mimicking lymphoma: a diagnostic challenge. Clinical journal of gastroenterology 19 (2),367-374頁 2026/04
論文	Predictive Value of Serum Autotaxin for Hepatocellular Carcinoma Recurrence After Curative Radiofrequency Ablation. Cancer medicine 15 (1),e71506 2026/01
論文	A CRISPR-based genome-wide loss-of-function screen defines a role of host metabolism in regulating hepatitis B virus infection. Molecular therapy : the journal of the American Society of Gene Therapy 2025/12/01
論文	Alteration of Gene Expression After Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver Viruses 2024/11/06
論文	Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice. Virus research 349,199451-199451頁 2024/11
論文	Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy. Scientific reports 14 (1),25584-25584頁 2024/10/26
論文	Association of Hepatobiliary Phase of Gadoxetic-Acid-Enhanced MRI Imaging with Immune Microenvironment and Response to Atezolizumab Plus Bevacizumab Treatment. Cancers 15 (17) 2023/08/24
論文	Correlation between serum pro-inflammatory cytokine levels and the prognosis of the patients with acute liver failure. Journal of gastroenterology and hepatology 2023/07/20
論文	Serum interleukin-6 level predicts the prognosis for patients with alcohol-related acute-on-chronic liver failure. Hepatology international 2023/04/26
論文	Acute liver injury in a non-alcoholic fatty liver disease patient with chloroform exposure: a case report. Clinical journal of gastroenterology 16 (2),250-253頁 2023/04
論文	HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice. Hepatology (Baltimore, Md.) 2023/03/13
論文	The Analysis of Muscle Volume Measured by Bioelectrical Impedance in Patients with Hepatocellular Carcinoma Treated with First-Line Atezolizumab plus Bevacizumab Combination Therapy or First-Line Lenvatinib. Oncology 101 (8),491-501頁 2023
論文	A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system. Journal of viral hepatitis 2022/12/27
論文	Hepatic venous pressure gradient after balloon-occluded retrograde transvenous obliteration and liver stiffness measurement predict the prognosis of patients with gastric varices. BMC gastroenterology 22 (1),535-535頁 2022/12/22
論文	The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma. International journal of cancer 2022/08/19
論文	Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study. BMC gastroenterology 22 (1),275-275頁 2022/06/02
論文	A dual conditional CRISPR-Cas9 system to activate gene editing and reduce off-target effects in human stem cells Molecular Therapy - Nucleic Acids 2022/06
論文	HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of their replication by TRAIL. The Journal of infectious diseases 2022/02/28
論文	Promoting mechanism of serum amyloid a family expression in mouse intestinal epithelial cells. PloS one 17 (3),e0264836 2022
論文	The importance of body composition assessment for patients with advanced hepatocellular carcinoma by bioelectrical impedance analysis in lenvatinib treatment. PloS one 17 (1),e0262675 2022
論文	Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection. Molecular therapy. Methods & clinical development 23,597-605頁 2021/12/10
論文	Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-infected human hepatocyte transplanted mice. Biochemical and biophysical research communications 559,78-83頁 2021/06/25
論文	Abatacept treatment for patients with severe acute hepatitis caused by hepatitis B virus infection-Pilot study JOURNAL OF VIRAL HEPATITIS 28 (2),400-409頁 2021/02
論文	In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism MOLECULAR MEDICINE REPORTS 23 (1) 2021/01
論文	Publisher Correction: Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP (Scientific Reports, (2019), 9, 1, (8462), 10.1038/s41598-019-44934-5) Scientific Reports 10 (1) 2020/12/01
論文	Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion NATURE MICROBIOLOGY 5 (12),1532-+頁 2020/12
論文	Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection Journal of Clinical Investigation 2020/05/18
論文	Ribavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy Journal of Medical Virology 92 (2),210-218頁 2020/02
論文	Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice JOURNAL OF GASTROENTEROLOGY 54 (7),650-659頁 2019/07
論文	Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice JOURNAL OF GENERAL VIROLOGY 100 (7),1123-1131頁 2019/07
論文	Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP SCIENTIFIC REPORTS 9 2019/06/11
論文	HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response GASTROENTEROLOGY 156 (8),2313-+頁 2019/06
論文	Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection VIRUSES-BASEL 11 (3) 2019/03/15
論文	Correction: Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: a pilot study. Antiviral therapy 23 (8),709 2019
論文	Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures. Journal of gastroenterology 54 (3),291-296頁 2018/10
論文	Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes. Virology 525,48-61頁 2018/09
論文	Correction: Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers. Oncotarget 9 (60),31789-31789頁 2018/08
論文	Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure. The Journal of general virology 99 (8),1058-1065頁 2018/08
論文	CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients. Journal of viral hepatitis 25 (12),1555-1564頁 2018/07
論文	Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice Biochemical and Biophysical Research Communications 500 (2),152-157頁 2018/06/02
論文	Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: a pilot study. Antiviral therapy 23 (8),709-709頁 2018/06
論文	Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. The Journal of infectious diseases 217 (11),1761-1769頁 2018/05
論文	B型肝炎 HBs抗原陰性化を目指した治療戦略新規ペグ化インターフェロンβによるB型肝炎ウイルスに対する抗ウイルス効果の検討肝臓 59 (Suppl.1),A117-A117頁 2018/04
論文	Characterization of recombinant Flaviviridae viruses possessing a small reporter Tag Journal of Virology 92 (2) 2018/01/01
論文	Erratum to: Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy (Journal of Gastroenterology, (2018), 53, 1, (107-118), 10.1007/s00535-017-1348-8) Journal of Gastroenterology 53 (1),107-118頁 2018/01/01
論文	Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy Journal of Gastroenterology 53 (1),161-162頁 2018/01/01
論文	The association between serum cytokine and chemokine levels and antiviral response by entecavir treatment in chronic hepatitis B patients. Antiviral therapy 23 (3),239-248頁 2018
論文	Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus ANTIVIRAL RESEARCH 146,130-138頁 2017/10
論文	Engineering of Small Reporter-Tagged Flaviviridae Viruses Applicable to Antiviral Screening and in vivo Dynamics 2017/09
論文	Persistent Loss of Hepatitis B Virus Markers in Serum without Cellular Immunity by Combination of Peginterferon and Entecavir Therapy in Humanized Mice ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 61 (9) 2017/09
論文	Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 61 (6) 2017/06
論文	Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology JOURNAL OF GENERAL VIROLOGY 98 (5),1040-1047頁 2017/05
論文	B型肝炎研究の新展開 B型肝炎ウイルス(HBV)感染に伴う肝細胞内IL8発現亢進と細胞内インターフェロン反応性の検討肝臓 58 (Suppl.1),A45-A45頁 2017/04
論文	Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus PLOS ONE 12 (3),e0172412 2017/03
論文	Protease Inhibitor Resistance Remains Even After Mutant Strains Become Undetectable by Deep Sequencing JOURNAL OF INFECTIOUS DISEASES 214 (11),1687-1694頁 2016/12
論文	Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection JOURNAL OF GASTROENTEROLOGY 51 (11),1073-1080頁 2016/11
論文	Improvement of renal dysfunction in a patient with hepatitis C virus-related liver cirrhosis by daclatasvir and asunaprevir combination therapy: A case report HEPATOLOGY RESEARCH 46 (9),944-948頁 2016/08
論文	NS3プロテアーゼ阻害薬治療後の同系薬剤に対する感受性の検討肝臓 57 (Suppl.1),A336-A336頁 2016/04
論文	ヒト肝細胞キメラマウスを用いたB型肝炎ウイルス遺伝子型による感染肝細胞内遺伝子発現変化の検討日本臨床分子医学会学術総会プログラム・抄録集 53回,73-73頁 2016/04
論文	Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice VIRUS RESEARCH 213,62-68頁 2016/02
論文	Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones JOURNAL OF INFECTION 72 (1),91-102頁 2016/01
論文	Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice ANTIVIRAL THERAPY 21 (4),307-315頁 2016
論文	腹部造影CTにより診断され，内視鏡的に止血し得た小腸憩室出血の1例日本消化器内視鏡学会雑誌 58 (4),970-975頁 2016
論文	Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice JOURNAL OF VIROLOGY 89 (19),10087-10096頁 2015/10
論文	Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A JOURNAL OF HEPATOLOGY 63 (3),554-563頁 2015/09
論文	C型慢性肝炎に対するシメプレビル+PEG-IFN/RBV療法における治療前耐性変異と治療効果の関連肝臓 56 (Suppl.2),A706-A706頁 2015/09
論文	ヒト肝細胞キメラマウスを用いた高用量ETV/PEG-IFN投与による抗HBV効果の検討肝臓 56 (Suppl.2),A757-A757頁 2015/09
論文	Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay PLOS ONE 10 (6),e0130022 2015/06
論文	HCV感染ヒト肝細胞キメラマウスを用いたIFN投与後の免疫応答の解析肝臓 56 (Suppl.1),A319-A319頁 2015/04
論文	HCV慢性感染肝組織内でのOAS1発現は自身近傍のSNPよりもIL28B近傍のSNPにより強く調節される肝臓 56 (Suppl.1),A315-A315頁 2015/04
論文	核酸アナログ中止例におけるHBVコア蛋白のアミノ酸変異に関する解析肝臓 56 (Suppl.1),A404-A404頁 2015/04
論文	HCV持続感染におけるIFNL4とHLA-DQの遺伝子多型間相互作用日本消化器病学会雑誌 112 (臨増総会),A354-A354頁 2015/03
論文	膵癌に発症した化膿性膵管炎の1例 Gastroenterological Endoscopy 57 (3),247-253頁 2015/03
論文	The IL28B SNP has a stronger regulatory effect on the expression of OAS1 than a nearby SNP located downstream of OAS1 in chronic HCV patients HEPATOLOGY 60,1077A-1077A頁 2014