研究者総覧 - 小林　隆志

コバヤシ　タカシ
小林　隆志

所属大分大学医学部基礎医学・感染予防医学

職種教授

論文
論文	Envelope protein residue E152 confers enhanced GAS6-dependent cell entry to the African Zika virus strain MR766. Antiviral research 252,106462-106462頁 2026/08
論文	The CCL20-CCR6 axis predominantly drives IL-17-mediated psoriasis while modestly contributing to papain-induced type 2 inflammation. International immunology 2026/07/11
論文	Anisakis infection induces IgE responses resulting from ILC2 and Th2 cell activation via IL-33 in the murine stomach. Parasitology international 111,103184-103184頁 2026/04
論文	Annexin A8 drives MEK inhibitor resistance, providing a druggable target for pancreatic ductal adenocarcinoma. Molecular cancer therapeutics 25 (7),1195-1207頁 2026/01/29
論文	Zika virus exacerbates EAE by inducing the production of T cell-attracting chemokines in astrocytes. International immunology 38 (5),318-334頁 2025/12/17
論文	CCL9/CCR1 chemokine signaling plays a protective role in limiting intestinal inflammation by maintaining an anti-inflammatory M2 macrophage pool in the intestinal lamina propria. Biochemical and biophysical research communications 786,152763-152763頁 2025/10/30
論文	Lipid mediator palmitoylethanolamide (PEA) inhibits pathogenic T cell differentiation in vitro and in vivo. Biochemical and biophysical research communications 743,151085-151085頁 2025/01
論文	消化管疾患と東洋医学好中球プロテアーゼの制御による大建中湯の腸管上皮保護作用の解析日本消化管学会雑誌 9 (Suppl.),177-177頁 2025/01
論文	IFN-γ-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America 121 (48),e2401692121 2024/11/26
論文	CCR2-dependent placental migration of inflammatory monocytes suppresses abnormal pregnancies caused by Toxoplasma gondii infection. International immunology 37 (1),39-52頁 2024/11/25
論文	Loss of O6-methylguanine DNA methyltransferase (MGMT) in macrophages alters responses to TLR3 stimulation and enhances DNA double-strand breaks and mitophagy Scientific Reports 14 (1),27492 2024/11/11
論文	Daikenchuto, a Japanese herbal medicine, ameliorates experimental colitis in a murine model by inducing secretory leukocyte protease inhibitor and modulating the gut microbiota. Frontiers in immunology 15,1457562-1457562頁 2024/10/25
論文	Colon protective effect of Japanese Kampo medicine Daikenchuto by modulating gut microbiota and inducing SLPI Clinical Nutrition ESPEN 63,1167-1168頁 2024/10
論文	Tff1-expressing Tregs in lung prevent exacerbation of Bleomycin-induced pulmonary fibrosis. Frontiers in immunology 15,1440918-1440918頁 2024/09/02
論文	TRAF6 signaling in T cells is crucial for the pathogenicity of experimental autoimmune encephalomyelitis International Immunology 36 (5),241-256頁 2024/04/03
論文	大腸内視鏡検査で治療経過を追ったメトロニダゾール抵抗性アメーバ性大腸炎大分県医学会雑誌 31,48-52頁 2024/03
論文	CCL20/CCR6系は実験的自己免疫性脳脊髄炎に必ずしも必要ではない(CCL20/CCR6 axis is not necessarily required for experimental autoimmune encephalomyelitis) 日本免疫学会総会・学術集会記録 52 (Proceedings),391-391頁 2023/12
論文	GM-CSF産生CCR2+CCR6+Th17細胞はマウスDSS腸炎において病原性である日本消化器病学会雑誌 120 (臨増大会),A775-A775頁 2023/10
論文	Tocilizumab-induced mucosal injury in the terminal ileum mimicking intestinal Behçet's disease: A case report. Medicine 102 (25),e34118 2023/06/23
論文	TRAF6 signaling in dendritic cells plays protective role against infectious colitis by limiting C. rodentium infection through the induction of Th1 and Th17 responses. Biochemical and biophysical research communications 669,103-112頁 2023/05/27
論文	Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression. mBio 14 (1),e0325622 2023/01/30
論文	Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor. Cancer science 114 (5),2189-2202頁 2023/01/24
論文	GM-CSF-producing CCR2+ CCR6+ Th17 cells are pathogenic in DSS-induced colitis model in mice. Genes to cells : devoted to molecular & cellular mechanisms 28 (4),267-276頁 2023/01/14
論文	エビデンスに基づく漢方診療抗菌薬で生じるリーキーガットに対する柴苓湯の保護効果に関する基礎研究日本消化管学会雑誌 7 (Suppl.),223-223頁 2023/01
論文	COVID-19 vaccination and liver disease. World journal of gastroenterology 28 (48),6791-6810頁 2022/12/28
論文	CCL20/CCR6 chemokine signaling is not essential for pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Biochemical and biophysical research communications 641,123-131頁 2022/11/30
論文	サイトカインとケモカイン-1 ケモカインCCL20とその受容体CCR6の多発性硬化症マウスにおける生理的機能(Cytokines and Chemokines-1 Physiological function of chemokine CCL20 and its receptor CCR6 in multiple sclerosis in mice) 日本免疫学会総会・学術集会記録 51 (Proceedings),WS17-P頁 2022/11
論文	サイトカインとケモカイン-2 ケモカイン受容体欠損マウスを用いた消化管における病原性Th17細胞の同定(Cytokines and Chemokines-2 Identification of pathogenic Th17 cells in gastrointestinal tract using chemokine receptor deficient mice) 日本免疫学会総会・学術集会記録 51 (Proceedings),WS25-P頁 2022/11
論文	感染と免疫I ジカウイルスが中枢神経系に病原性T細胞誘引ケモカインを誘導し実験的自己免疫性脳脊髄炎を増悪させる(Infection and Immunity I Zika virus induces pathogenic T cell-attracting chemokines in the central nervous system and exacerbates experimental autoimmune encephalomyelitis) 日本免疫学会総会・学術集会記録 51 (Proceedings),WS03-P頁 2022/11
論文	感染と免疫II 樹状細胞におけるTRAF6シグナル伝達のC.rodentium感染制御における生理的関連性(Infection and Immunity II Physiological relevance of TRAF6 signaling in dendritic cells in controlling C. rodentium infection) 日本免疫学会総会・学術集会記録 51 (Proceedings),WS12-P頁 2022/11
論文	粘膜-皮膚免疫分泌型白血球プロテアーゼ阻害剤は腸上皮バリアの保護によりマウス実験的大腸炎を改善する(Mucosal-Skin Immunity Secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier) 日本免疫学会総会・学術集会記録 51 (Proceedings),WS07-P頁 2022/11
論文	Dysbiosisに起因するLeaky gutモデルに対する柴苓湯の有効性日本消化器病学会雑誌 119 (臨増大会),A776-A776頁 2022/10
論文	ケモカイン受容体欠損マウスを用いた病原性・制御性Th17細胞に関する研究日本消化器病学会雑誌 119 (臨増大会),A775-A775頁 2022/10
論文	Acute Cholecystitis Associated with Eosinophilic Granulomatosis with Polyangiitis that Responded to Glucocorticoid Therapy. Internal medicine (Tokyo, Japan) 62 (10),1501-1506頁 2022/09/28
論文	Transcriptional coregulator Ess2 controls survival of post-thymic CD4+ T cells through the Myc and IL-7 signaling pathways. The Journal of biological chemistry,102342-102342頁 2022/08/03
論文	TRAF6 signaling pathway in T cells regulates anti-tumor immunity through the activation of tumor specific Th9 cells and CTLs Biochemical and Biophysical Research Communications 613,26-33頁 2022/07
論文	Comment on "A case of acute necrotising pancreatitis following the second dose of Pfizer-BioNTech COVID-19 mRNA vaccine". British journal of clinical pharmacology 88 (5),2449-2449頁 2022/05
論文	Comprehensive lipidomics of lupus-prone mice using LC-MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9-mediated inflammation. Genes to cells : devoted to molecular & cellular mechanisms 2022/04/29
論文	Acute pancreatitis soon after COVID-19 vaccination: A case report. Medicine 101 (2),e28471 2022/01/14
論文	Saireito, a Japanese herbal medicine, alleviates leaky gut associated with antibiotic-induced dysbiosis in mice. PloS one 17 (6),e0269698 2022
論文	Anisakis幼虫感染における発症メカニズムの解析(Analysis of pathogenic mechanism in Anisakis larvae infection) 日本免疫学会総会・学術集会記録 50 (Proceedings),2-P頁 2021/11
論文	マウス腸炎モデルを用いた大建中湯のSLPI発現増強を介した腸管保護作用の解析日本消化器病学会雑誌 118 (臨増大会),A701-A701頁 2021/10
論文	Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10. Biochemical and biophysical research communications 570,60-66頁 2021/09/17
論文	Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier Genes to Cells 2021/08/17
論文	The Roles of IL-17, IL-21, and IL-23 in the Helicobacter pylori Infection and Gastrointestinal Inflammation: A Review. Toxins 13 (5) 2021/04/28
論文	Analysis of the prevalence and species of Anisakis nematode in Sekisaba, Scomber japonicus caught in coastal waters off Saganoseki, Oita in Japan. Japanese journal of infectious diseases 74 (5),387-391頁 2021/01/29
論文	Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential Pathobiology 88 (5),374-382頁 2021
論文	The Lethal(2)-Essential-for-Life [L(2)EFL] Gene Family Modulates Dengue Virus Infection in Aedes aegypti. International journal of molecular sciences 21 (20) 2020/10/12
論文	DSS腸炎モデルを用いたSLPIの結腸における生理的機能の解析日本消化器病学会雑誌 117 (臨増大会),A728-A728頁 2020/10
論文	ZNF395の発現低下は膵癌の増殖能亢進と進展に寄与する日本癌学会総会記事 79回,PJ14-9頁 2020/10
論文	DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells Biochemical and Biophysical Research Communications 528 (3),586-593頁 2020/07
論文	Development of a portable reverse transcription loop-mediated isothermal amplification system to detect the E1 region of Chikungunya virus in a cost-effective manner. Genes to cells : devoted to molecular & cellular mechanisms 25 (9),615-625頁 2020/06/19
論文	CLP1 acts as the main RNA kinase in mice Biochemical and Biophysical Research Communications 525 (1),129-134頁 2020/04
論文	Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of pancreatic ductal adenocarcinoma. Surgery today 50 (7),767-777頁 2020/01/16
論文	Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice. Inflammatory intestinal diseases 3 (3),145-154頁 2019/02
論文	Th2型炎症(抑制因子TRAF6cKO/アニサキス感染)による腸内細菌叢への影響日本衛生学雑誌 74 (Suppl.),S177-S177頁 2019/02
論文	Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis. Ann Dermatol. 31 (6),631-639頁 2019
論文	IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse Scientific Reports 8 (1) 2018/12/01
論文	Oral administration of antibiotics results in fecal occult bleeding due to metabolic disorders and defective proliferation of the gut epithelial cell in mice. Genes to cells : devoted to molecular & cellular mechanisms 23 (12),1043-1055頁 2018/12
論文	Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis. Clinical & experimental metastasis 35 (8),785-796頁 2018/12
論文	Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation. International journal of molecular sciences 19 (10),E3043 2018/10/05
論文	Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice. Biochemical and biophysical research communications 504 (1),245-250頁 2018/09/26
論文	Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation JCI insight 3 (15),121175 2018/08/09
論文	Supermolecular drug challenge to overcome drug resistance in cancer cells. Drug discovery today 23 (8),1556-1563頁 2018/08
論文	Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains. Biochemical and biophysical research communications 497 (2),597-604頁 2018/03/04
論文	Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling. The Journal of experimental medicine 215 (2),501-519頁 2018/02/05
論文	Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice. Antiviral research 146,1-11頁 2017/10
論文	STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System MBIO 7 (6),e01881-16 2016/11
論文	チカイエカCulex pipiens f. molestus (Diptera: Culicidae) の雌の翅長と卵粒数に及ぼす温度と幼虫期の餌量の影響都市有害生物管理 6 (1),1-7頁 2016
論文	Reduced Tyk2 gene expression in beta-cells due to natural mutation determines susceptibility to virus-induced diabetes NATURE COMMUNICATIONS 6,6748 2015/04
論文	Medicinal facilities to B16F10 melanoma cells for distant metastasis control with a supramolecular complex by DEAE-dextran-MMA copolymer/paclitaxel DRUG DELIVERY AND TRANSLATIONAL RESEARCH 5 (1),38-50頁 2015/02
論文	Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl-dextran-MMA graft copolymer and paclitaxel used as an artificial enzyme BEILSTEIN JOURNAL OF NANOTECHNOLOGY 5,2293-2307頁 2014/12
論文	Dengue transmission model by means of viremic adult immuno-competent mouse PARASITES & VECTORS 7 (1),143 2014/03
論文	Multiple infections with helminths - whipworm, hookworm, and roundworm ENDOSCOPY 46 (Suppl 1),E117-E118頁 2014/01
論文	Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b GENE 530 (1),19-25頁 2013/11
論文	TRAF6 Is Essential for Maintenance of Regulatory T Cells That Suppress Th2 Type Autoimmunity PLOS ONE 8 (9),e74639 2013/09
論文	Supramolecular targeting of B16F10 melanoma cells with nanoparticles consisting of a DEAE-dextran-MMA copolymer-paclitaxel complex in vivo and in vitro. Journal of Nanomedicine & Biotherapeutic Discovery 2 (5),1-7頁 2012/12
論文	Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27 (4),938-49頁 2012/04
論文	TGF beta-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy JOURNAL OF BIOCHEMISTRY 151 (2),157-166頁 2012/02
論文	IL-1 beta and TNF alpha-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis INTERNATIONAL IMMUNOLOGY 23 (11),701-712頁 2011/11
論文	Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization JOURNAL OF EXPERIMENTAL MEDICINE 208 (11),2175-2181頁 2011/10
論文	A Germ Cell-specific Gene, Prmt5, Works in Somatic Cell Reprogramming JOURNAL OF BIOLOGICAL CHEMISTRY 286 (12),10641-10648頁 2011/03
論文	Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations INTERNATIONAL IMMUNOLOGY 23 (3),195-202頁 2011/03
論文	TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. (vol 283, pg 36211, 2008) JOURNAL OF BIOLOGICAL CHEMISTRY 284 (52),36720-36720頁 2009/12
論文	A Major Lipid Raft Protein Raftlin Modulates T Cell Receptor Signaling and Enhances Th17-Mediated Autoimmune Responses JOURNAL OF IMMUNOLOGY 182 (10),5929-5937頁 2009/05
論文	Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. Immunity 30 (3),372-383頁 2009/05
論文	An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1 beta signaling pathway BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 381 (3),412-417頁 2009/04
論文	Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis RHEUMATOLOGY 48 (4),347-354頁 2009/04
論文	Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation CANCER SCIENCE 100 (4),730-736頁 2009/04
論文	TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses PLOS ONE 4 (3),e4736 2009/03
論文	FLN29 Deficiency Reveals Its Negative Regulatory Role in the Toll-like Receptor (TLR) and Retinoic Acid-inducible Gene I (RIG-I)-like Helicase Signaling Pathway JOURNAL OF BIOLOGICAL CHEMISTRY 283 (49),33858-33864頁 2008/12
論文	Impaired Initiation of Contact Hypersensitivity by FTY720 JOURNAL OF INVESTIGATIVE DERMATOLOGY 128 (12),2833-2841頁 2008/12
論文	TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway JOURNAL OF BIOLOGICAL CHEMISTRY 283 (52),36211-36220頁 2008/12
論文	Prostaglandin E(2) is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells INTERNATIONAL IMMUNOLOGY 20 (9),1219-1229頁 2008/09
論文	Foxp3 inhibits ROR gamma t-mediated IL-17A mRNA transcription through direct interaction with ROR gamma t JOURNAL OF BIOLOGICAL CHEMISTRY 283 (25),17003-17008頁 2008/06
論文	STAT6 inhibits TGF-beta 1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor JOURNAL OF BIOLOGICAL CHEMISTRY 283 (22),14955-14962頁 2008/05
論文	Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis HEPATOLOGY 47 (5),1644-1654頁 2008/05
論文	Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads JOURNAL OF IMMUNOLOGY 180 (6),3746-3756頁 2008/03
論文	Cutting edge: Requirement for TRAF6 in the induction of T cell anergy JOURNAL OF IMMUNOLOGY 180 (1),34-38頁 2008/01
論文	HTLV-1 tax-mediated TAK1 activation involves TAB2 adapter protein BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 365 (1),189-194頁 2008/01
論文	SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis IMMUNITY 27 (5),811-823頁 2007/11
論文	Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappa B activation in dendritic cells INTERNATIONAL IMMUNOLOGY 19 (8),935-942頁 2007/08
論文	Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells JOURNAL OF IMMUNOLOGY 179 (4),2170-2179頁 2007/08
論文	Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 359 (4),952-958頁 2007/08
論文	[Intracellular negative signals and allergy]. Arerugi = [Allergy] 56 (6),563-569頁 2007/06
論文	Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels MOLECULAR ENDOCRINOLOGY 21 (5),1120-1131頁 2007/05
論文	An RNA-binding protein alpha CP-1 is involved in the STAT3-mediated suppression of NF-kappa B transcriptional activity INTERNATIONAL IMMUNOLOGY 19 (5),609-619頁 2007/05
論文	Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin NATURE IMMUNOLOGY 8 (3),304-311頁 2007/03
論文	A novel zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling (vol 344, pg 1023, 2006) BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353 (4),1121-1121頁 2007/02
論文	The dual function of hepatic SOCS3 in insulin resistance in vivo GENES TO CELLS 12 (2),143-154頁 2007/02
論文	Positive and negative roles of IL-6, STAT3, and SOCS3 in inflammatory arthritis. Advances in experimental medicine and biology 602,113-124頁 2007
論文	Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic JOURNAL OF BIOLOGICAL CHEMISTRY 281 (48),36683-36690頁 2006/12
論文	TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis NATURE MEDICINE 12 (9),1088-1092頁 2006/09
論文	TGF-beta 1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation GENES TO CELLS 11 (8),871-882頁 2006/08
論文	Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis GASTROENTEROLOGY 131 (1),179-193頁 2006/07
論文	A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 344 (3),1023-1030頁 2006/06
論文	IFN gamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice JOURNAL OF EXPERIMENTAL MEDICINE 203 (6),1391-1397頁 2006/06
論文	Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1 JOURNAL OF EXPERIMENTAL MEDICINE 203 (4),1021-1031頁 2006/04
論文	Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta 1 production ONCOGENE 25 (17),2520-2530頁 2006/04
論文	Mal-function of TLRs by SOCS NATURE IMMUNOLOGY 7 (2),123-124頁 2006/02
論文	Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFN gamma and IL-4 are involved GASTROENTEROLOGY 130 (2),373-388頁 2006/02
論文	FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling JOURNAL OF BIOLOGICAL CHEMISTRY 280 (50),41289-41297頁 2005/12
論文	Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis JOURNAL OF EXPERIMENTAL MEDICINE 202 (5),589-595頁 2005/09
論文	Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia NATURE NEUROSCIENCE 8 (7),855-857頁 2005/07
論文	Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene JOURNAL OF IMMUNOLOGY 174 (7),4325-4332頁 2005/04
論文	Keeping DCs awake by putting SOCS1 to sleep. Trends in immunology 26 (4),177-179頁 2005/04
論文	Suppressors of cytokine signaling-1 and-3 regulate osteoclastogenesis in the presence of inflammatory cytokines JOURNAL OF IMMUNOLOGY 174 (5),3024-3031頁 2005/03
論文	TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii INFECTION AND IMMUNITY 72 (10),5662-5667頁 2004/10
論文	TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease JOURNAL OF IMMUNOLOGY 171 (11),5751-5759頁 2003/12
論文	TRAF6 is a critical factor for dendritic cell maturation and development IMMUNITY 19 (3),353-363頁 2003/09
論文	Utilization of knockout mice to examine the potential role of gastric histamine H-2-receptors in Menetrier's disease JOURNAL OF PHARMACOLOGICAL SCIENCES 91 (1),61-70頁 2003/01
論文	The role of histamine in the regulation of T-cell and antibody responses ALLERGY FRONTIERS AND FUTURES,82-86頁 2003
論文	Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling JOURNAL OF EXPERIMENTAL MEDICINE 196 (7),923-934頁 2002/10
論文	SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast MECHANISMS OF DEVELOPMENT 118 (1-2),99-109頁 2002/10
論文	Distinct molecular mechanism for initiating TRAF6 signalling NATURE 418 (6896),443-447頁 2002/07
論文	Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors NATURE 413 (6854),420-425頁 2001/09
論文	Functional and morphological abnormality of gastric mucosa in histamine H2 receptor (H2R)-deficient mice HISTAMINE RESEARCH IN THE NEW MILLENNIUM 1224,229-234頁 2001
論文	Immediate-type hypersensitivity and helper T cell function in histamine H1 receptor- and H2 receptor-deficient mice. HISTAMINE RESEARCH IN THE NEW MILLENNIUM 1224,395-396頁 2001
論文	Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice JOURNAL OF CLINICAL INVESTIGATION 105 (12),1741-1749頁 2000/06
論文	Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97 (12),6874-6879頁 2000/06
論文	Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 8 (5),296-307頁 1997/09
論文	Cytomegalovirus enhancer chicken beta-actin promoter confers constitutive and ubiquitous transgene expression in vivo TRANSGENICS 2 (2),153-&頁 1997
論文	Cloning, RNA expression and chromosomal location of a mouse histamine H2 receptor gene GENOMICS 37 (3),390-394頁 1996/11
論文	Impaired locomotor activity and exploratory behavior in mice lacking histamine H-1 receptors PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 93 (23),13316-13320頁 1996/11
論文	Accumulation of beta-amyloid fibrils in pancreas of transgenic mice NEUROBIOLOGY OF AGING 17 (2),215-222頁 1996/03
論文	The ter mutation responsible for germ cell deficiency but not testicular nor ovarian teratocarcinogenesis in ter/ter congenic mice DEVELOPMENT GROWTH & DIFFERENTIATION 38 (1),59-69頁 1996/02
論文	Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 218 (1),238-242頁 1996/01
論文	Genetic ablation of osteoblasts causes osteopenia without affecting osteoclastogenesis in transgenic mice. Transgenics 1,649-662頁 1995