研究者総覧 - 石崎　敏理

イシザキ　トシマサ
石崎　敏理

所属大分大学医学部基礎医学・薬理学

職種教授

論文
論文	Investigation in the selective targeting of homologous recombination-deficient cells by benzophenanthridine alkaloid nitidine. Scientific reports 2026/07/08
論文	Mitotic abnormality induced by evodiamine, a tryptamine indole alkaloid Toxicology and Applied Pharmacology,117813-117813頁 2026/06
論文	RPE With ROCK-Mediated Epithelial-Mesenchymal Transition as a Key Contributor of Subretinal Fibrosis in AMD Investigative Ophthalmology & Visual Science 67 (5),33-33頁 2026/05/14
論文	Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis. Journal of dermatological science 119 (1),9-17頁 2025/07
論文	Analysis of accumulation of DNA double-strand breaks in mouse tissues by pulsed-field gel electrophoresis Toxicology and Applied Pharmacology 497,117278-117278頁 2025/04
論文	Timosaponin AIII Disrupts Cell–Extracellular Matrix Interactions through the Inhibition of Endocytic Pathways Biological and Pharmaceutical Bulletin 47 (10),1648-1656頁 2024/10/11
論文	Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice FEBS open bio 14 (6),906-921頁 2024/06
論文	Caspase-4 has a role in cell division in epithelial cells through actin depolymerization Biochemical and Biophysical Research Communications 695,149394-149394頁 2024/02/05
論文	Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition Communications Biology 5 (1),982-982頁 2022/09/16
論文	A novel mRNA decay inhibitor abolishes pathophysiological cellular transition. Cell death discovery 8 (1),278-278頁 2022/06/07
論文	Involvement of activator protein-1 family members in β-catenin and p300 association on the genome of PANC-1 cells. Heliyon 8 (2),e08890 2022/02
論文	The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants. Scientific reports 11 (1),7718-7718頁 2021/04/08
論文	Timosaponin Aiii Disrupts Morphological Plasticity and Migration of Breast Adenocarcinoma Through Inhibition of Integrin Internalisation 2021/03/15
論文	Timosaponin AIII disturbs morphological plasticity and migration by suppressing membrane dynamics. Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (0),2-P2頁 2021
論文	Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction. Cardiovascular research 117 (4),1103-1117頁 2020/07/09
論文	mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse. Science advances 6 (1),eaay2432 2020/01
論文	Analysis of Chromosomal DNA Fragmentation in Apoptosis by Pulsed-Field Gel Electrophoresis. Methods in molecular biology (Clifton, N.J.) 2119,89-99頁 2020
論文	1181Role of rho-mdia1 signaling to maintain cardiac function in response to pressure overload in mice European Heart Journal 40 (Supplement_1) 2019/10/01
論文	IRR is involved in glucose-induced endocytosis after insulin secretion. Journal of pharmacological sciences 140 (3),300-304頁 2019/07
論文	GDP-Bound Rab27a Dissociates from the Endocytic Machinery in a Phosphorylation-Dependent Manner after Insulin Secretion. Biological & pharmaceutical bulletin 42 (9),1532-1537頁 2019
論文	Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumor microenvironment. Genes to cells : devoted to molecular & cellular mechanisms 23 (6),466-479頁 2018/06
論文	Analysis of endocytic mechanisms in pancreatic beta-cells JOURNAL OF PHARMACOLOGICAL SCIENCES 133 (3),S237 2017/03
論文	Identification and characterization of a novel GDP-bound Rab27a interacting protein in pancreatic beta-cells JOURNAL OF PHARMACOLOGICAL SCIENCES 133 (3),S237 2017/03
論文	Regulation of the glucose-induced endocytosis via Rab27a-GAP in pancreatic beta-cells JOURNAL OF PHARMACOLOGICAL SCIENCES 133 (3),S142 2017/03
論文	PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a. Journal of cell science 129 (3),637-49頁 2016/02/01
論文	Protective effect of hydrogen sulfide on pancreatic beta-cells. Nitric oxide : biology and chemistry 46,32-6頁 2015/04/30
論文	Interplay between Rab27a effectors in pancreatic β-cells. World journal of diabetes 6 (3),508-16頁 2015/04/15
論文	GTP- and GDP-Dependent Rab27a Effectors in Pancreatic Beta-Cells. Biological & pharmaceutical bulletin 38 (5),663-8頁 2015
論文	Molecular structures, cellular functions, and physiological roles of Rho effectors Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling,363-394頁 2014/05/01
論文	Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes NITRIC OXIDE-BIOLOGY AND CHEMISTRY 39,S31-S32頁 2014/05
論文	Actin nucleator, mDia1 and mDia3, cooperatively function in T cell receptor signaling-dependent T cell development in thymus JOURNAL OF PHARMACOLOGICAL SCIENCES 124,110P-110P頁 2014
論文	Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes JOURNAL OF PHARMACOLOGICAL SCIENCES 124,103P-103P頁 2014
論文	Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes. Biochemical and biophysical research communications 442 (3-4),227-33頁 2013/12/13
論文	Activated Cdc42-bound IQGAP1 determines the cellular endocytic site. Molecular and cellular biology 33 (24),4834-43頁 2013/12
論文	Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. Cell reports 5 (4),926-32頁 2013/11/27
論文	EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination. Genes to cells : devoted to molecular & cellular mechanisms 18 (10),873-85頁 2013/10
論文	Citron kinase mediates transition from constriction to abscission through its coiled-coil domain. Journal of cell science 126 (Pt 8),1773-84頁 2013/04/15
論文	Roles of mDia, a Rho effector and formin family actin-nucleator, in T cell development JOURNAL OF PHARMACOLOGICAL SCIENCES 121,63P-63P頁 2013
論文	A new role of multi scaffold protein Liprin-α: Liprin-α suppresses Rho-mDia mediated stress fiber formation. Bioarchitecture 2 (2),43-49頁 2012/02/01
論文	A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. Nature neuroscience 15 (3),373-80頁 2012/01/15
論文	Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization. Journal of cell science 125 (Pt 1),108-20頁 2012/01/01
論文	Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II. Genes to cells : devoted to molecular & cellular mechanisms 16 (10),1012-21頁 2011/10
論文	Rotational movement of the formin mDia1 along the double helical strand of an actin filament. Science (New York, N.Y.) 331 (6013),80-3頁 2011/01/07
論文	Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia. PloS one 6 (9),e25465 2011
論文	mDia, an actin nucleator and a Rho effector, is critical for tangential migration of cortical and olfactory bulb inhibitory interneuron precursors NEUROSCIENCE RESEARCH 71,E130-E130頁 2011
論文	Roles of mDia isoforms, a Rho effector, in neuroblast migration JOURNAL OF PHARMACOLOGICAL SCIENCES 115,133P-133P頁 2011
論文	Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells BLOOD 116 (26),5875-5884頁 2010/12
論文	mDia1 Targets v-Src to the Cell Periphery and Facilitates Cell Transformation, Tumorigenesis, and Invasion MOLECULAR AND CELLULAR BIOLOGY 30 (19),4604-4615頁 2010/10
論文	Rho and Anillin-dependent Control of mDia2 Localization and Function in Cytokinesis MOLECULAR BIOLOGY OF THE CELL 21 (18),3193-3204頁 2010/09
論文	Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells CELL STEM CELL 7 (2),225-239頁 2010/08
論文	Roles of mDia isoforms, a Rho effector, in neural development NEUROSCIENCE RESEARCH 68,E138-E138頁 2010
論文	Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion CANCER AND METASTASIS REVIEWS 28 (1-2),65-76頁 2009/06
論文	mDia2 Shuttles between the Nucleus and the Cytoplasm through the Importin-alpha/beta- and CRM1-mediated Nuclear Transport Mechanism JOURNAL OF BIOLOGICAL CHEMISTRY 284 (9),5753-5762頁 2009/02
論文	Roles of mDia, a Rho effector, in neural development NEUROSCIENCE RESEARCH 65,S95-S95頁 2009
論文	mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells MOLECULAR BIOLOGY OF THE CELL 19 (5),2328-2338頁 2008/05
論文	mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells MOLECULAR BIOLOGY OF THE CELL 19 (5),2328-2338頁 2008/05
論文	Dissecting the role of putative mDia-binding protein in neuron JOURNAL OF PHARMACOLOGICAL SCIENCES 106,135P-135P頁 2008
論文	The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src MOLECULAR AND CELLULAR BIOLOGY 26 (18),6844-6858頁 2006/09
論文	GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins JOURNAL OF BIOLOGICAL CHEMISTRY 281 (15),9891-9900頁 2006/04
論文	ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. The Journal of cell biology 168 (6),941-53頁 2005/03/14
論文	Cdc42 and mDia3 regulate microtubule attachment to kinetochores NATURE 428 (6984),767-771頁 2004/04
論文	Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death MOLECULAR AND CELLULAR BIOLOGY 23 (14),5043-5055頁 2003/07
論文	Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Molecular and cellular biology 23 (14),5043-55頁 2003/07
論文	Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II MOLECULAR BIOLOGY OF THE CELL 14 (5),1745-1756頁 2003/05
論文	Rho情報伝達経路とその生理的意義日本薬理学雑誌 121 (3),153-162頁 2003
論文	ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts JOURNAL OF CELL BIOLOGY 157 (5),819-830頁 2002/05
論文	Focal contacts as mechanosensors: Externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism JOURNAL OF CELL BIOLOGY 153 (6),1175-1185頁 2001/06
論文	Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1 NATURE CELL BIOLOGY 3 (1),8-14頁 2001/01
論文	Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells Journal of Cell Science 114 (4),775-784頁 2001
論文	Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells Journal of Cell Science 114 (18),3273-3284頁 2001
論文	Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow ONCOGENE 19 (52),6059-6064頁 2000/12
論文	Pharmacological properties of Y-27632, a specific inhibitor of Rho-associated kinases MOLECULAR PHARMACOLOGY 57 (5),976-983頁 2000/05
論文	Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop JOURNAL OF BIOLOGICAL CHEMISTRY 275 (5),3577-3582頁 2000/02
論文	A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons Neuron 26 (2),431-441頁 2000
論文	Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella Journal of Cell Science 113 (1),103-112頁 2000
論文	Signaling from rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase SCIENCE 285 (5429),895-898頁 1999/08
論文	An essential part for Rho-associated kinase in the transcellular invasion of tumor cells NATURE MEDICINE 5 (2),221-225頁 1999/02
論文	Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of the sperm tail FEBS LETTERS 445 (1),9-13頁 1999/02
論文	Transformation mediated by RhoA requires activity of ROCK kinases CURRENT BIOLOGY 9 (3),136-145頁 1999/02
論文	p160ROCK mediates RhoA activation of Na-H exchange EMBO JOURNAL 17 (16),4712-4722頁 1998/08
論文	Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules JOURNAL OF BIOLOGICAL CHEMISTRY 273 (30),18943-18949頁 1998/07
論文	Role of citron kinase as a target of the small GTPase Rho in cytokinesis NATURE 394 (6692),491-494頁 1998/07
論文	Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells JOURNAL OF CELL BIOLOGY 141 (7),1625-1636頁 1998/06
論文	Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein Molecular and Cellular Biology 18 (5),3044-3058頁 1998
論文	Inhibition of Rho is required for cAMP-induced melanoma cell differentiation Molecular Biology of the Cell 9 (6),1367-1378頁 1998
論文	Integrin-dependent translocation of p160(ROCK) to cytoskeletal complex in thrombin-stimulated human platelets BIOCHEMICAL JOURNAL 328,769-775頁 1997/12
論文	p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin EMBO JOURNAL 16 (11),3044-3056頁 1997/06
論文	p160(ROCK), a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions FEBS LETTERS 404 (2-3),118-124頁 1997/03
論文	Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension Nature 389 (6654),990-994頁 1997
論文	Identification of the Rho-binding domain of p160(ROCK), a Rho-associated coiled-coil containing protein kinase JOURNAL OF BIOLOGICAL CHEMISTRY 271 (38),23022-23028頁 1996/09
論文	ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice FEBS LETTERS 392 (2),189-193頁 1996/08
論文	Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the Rho-binding domain JOURNAL OF BIOLOGICAL CHEMISTRY 271 (23),13556-13560頁 1996/06
論文	The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase EMBO JOURNAL 15 (8),1885-1893頁 1996/04
論文	Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho SCIENCE 271 (5249),645-648頁 1996/02
論文	A novel partner for the GTP-bound forms of rho and rac FEBS LETTERS 377 (2),243-248頁 1995/12
論文	IDENTIFICATION OF GLU(173) AS THE CRITICAL AMINO-ACID RESIDUE FOR THE ADP-RIBOSYLTRANSFERASE ACTIVITY OF CLOSTRIDIUM-BOTULINUM C3 EXOENZYME FEBS LETTERS 371 (2),105-109頁 1995/09
論文	LYSOPHOSPHATIDIC ACID-INDUCED ACTIVATION OF PROTEIN SER/THR KINASES IN CULTURED RAT 3Y1 FIBROBLASTS - POSSIBLE INVOLVEMENT IN RHO-P21-MEDIATED SIGNALING FEBS LETTERS 366 (1),11-16頁 1995/06
論文	Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding Journal of Virology 69 (5),3125-3133頁 1995/05
論文	A CELLULAR PROTEIN WHICH IS COPRECIPITATED WITH HTLV-I REX PROTEIN IN THE PRESENCE OF THE TARGET MESSENGER-RNA ONCOGENE 9 (12),3535-3544頁 1994/12
論文	Growth ability of human immunodeficiency virus type 1 auxiliary gene mutants in primary blood macrophage cultures Journal of General Virology 75 (9),2427-2431頁 1994