研究者総覧 - 松岡　茂

マツオカ　シゲル
松岡　茂

所属大分大学医学部臨床医学・臨床薬理学

職種特任教授

論文
論文	Intermolecular interactions of perfluoroalkyl acids with human heart-type fatty acid-binding protein International Journal of Biological Macromolecules,152710-152710頁 2026/05
論文	Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase including catalytic intermediates suggest an ordered Bi–Bi reaction mechanism Scientific Reports 2026/04/02
論文	Timosaponin AIII Disrupts Cell–Extracellular Matrix Interactions through the Inhibition of Endocytic Pathways Biological and Pharmaceutical Bulletin 47 (10),1648-1656頁 2024/10/11
論文	Protein-lipid acyl chain interactions: Depth-dependent changes of segmental mobility of phospholipid in contact with bacteriorhodopsin. Biophysical chemistry 308,107204-107204頁 2024/02/22
論文	Combined effect of the head groups and alkyl chains of archaea lipids when interacting with bacteriorhodopsin. Biophysical chemistry 294,106959-106959頁 2023/03
論文	Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition Communications Biology 5 (1) 2022/09/16
論文	Experimental and theoretical investigations into the mechanism of interactions between membrane-bound fatty acids and their binding protein: A model system to investigate the behavior of lipid acyl chains in contact with proteins Chemistry and Physics of Lipids,105227-105227頁 2022/08
論文	Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study. Science advances 8 (24),eabo2658 2022/06/17
論文	The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants. Scientific reports 11 (1),7718-7718頁 2021/04/08
論文	Timosaponin Aiii Disrupts Morphological Plasticity and Migration of Breast Adenocarcinoma Through Inhibition of Integrin Internalisation 2021/03/15
論文	Timosaponin AIII disturbs morphological plasticity and migration by suppressing membrane dynamics. Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (0),2-P2頁 2021
論文	Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia. EBioMedicine 62,103130-103130頁 2020/12
論文	他分野研究から迫る緑内障新規タンパク質部分構造擬態技術の確立と医療分野への展開日本緑内障学会抄録集 31回,57-57頁 2020/10
論文	A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder. Brain communications 2 (2),fcaa145 2020
論文	Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei FASEB J. 33 (11),13002-13013頁 2019/11
論文	The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein Sci. Adv. 4 (10),eaau1199 2018/10
論文	Enantioselective Deuteration of β-Substituted α,β-Unsaturated Esters by Rhodium-1,2-Bis(2,5-diphenylphospholano)ethane European Journal of Organic Chemistry 2018 (2),235-239頁 2018/01/17
論文	A three-dimensional movie of structural changes in bacteriorhodopsin SCIENCE 354 (6319),1552-1557頁 2016/12
論文	Enantioselective Deuteration of β-Substituted α,β-Unsaturated Esters by Rhodium-1,2-Bis(2,5-diphenylphospholano)ethane Science 354 (6319),1552-1557頁 2016/12
論文	Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113 (46),13039-13044頁 2016/11
論文	The Open Form Inducer Approach for Structure-Based Drug Design PLOS ONE 11 (11),e0167078 2016/11
論文	Impact of feline AIM on the susceptibility of cats to renal disease SCIENTIFIC REPORTS 6,35251 2016/10
論文	Evaluation of diacylphospholipids as boundary lipids for bacteriorhodopsin from structural and functional aspects BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1858 (9),2106-2115頁 2016/09
論文	5B35: Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA Worldwide Protein Data Bank 2016
論文	Centerband-only analysis of rotor-unsynchronized spin echo for measurement of lipid P-31 chemical shift anisotropy MAGNETIC RESONANCE IN CHEMISTRY 53 (7),514-519頁 2015/07
論文	Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior BIOORGANIC & MEDICINAL CHEMISTRY 23 (13),2989-2994頁 2015/07
論文	Erratum: Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions (Organic and Biomolecular Chemistry (015) DOI:10.1039/ c5ob01252j) Organic and Biomolecular Chemistry 13,10578 2015/01/01
論文	Molecular Dynamics Simulations of Heart-type Fatty Acid Binding Protein in Apo and Holo Forms, and Hydration Structure Analyses in the Binding Cavity JOURNAL OF PHYSICAL CHEMISTRY B 119 (1),114-127頁 2015/01
論文	Phosphatidylcholine bearing 6,6-dideuterated oleic acid: A useful solid-state H-2 NMR probe for investigating membrane properties BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25 (2),203-206頁 2015/01
論文	Water-Mediated Recognition of Simple Alkyl Chains by Heart-Type Fatty-Acid-Binding Protein ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54 (5),1508-1511頁 2015/01
論文	23pAA-1 FABP3の分子動力学シミュレーションおよびその結合ポケット内部の水和構造解析日本物理学会講演概要集 70,3374-3374頁 2015
論文	Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions ORGANIC & BIOMOLECULAR CHEMISTRY 13 (41),10279-10284頁 2015
論文	Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase MOLECULAR MICROBIOLOGY 94 (6),1315-1329頁 2014/12
論文	Interaction kinetics of liposome-incorporated unsaturated fatty acids with fatty acid-binding protein 3 by surface plasmon resonance BIOORGANIC & MEDICINAL CHEMISTRY 22 (6),1804-1808頁 2014/03
論文	Highly Efficient Preparation of Selectively Isotope Cluster-Labeled Long Chain Fatty Acids via Two Consecutive C-sp3-C-sp3 Cross-Coupling Reactions ORGANIC LETTERS 16 (3),844-847頁 2014/02
論文	Structure of the human-heart fatty-acid-binding protein 3 in complex with the fluorescent probe 1-anilinonaphthalene-8-sulphonic acid JOURNAL OF SYNCHROTRON RADIATION 20 (6),923-928頁 2013/11
論文	Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target JOURNAL OF BIOCHEMISTRY 154 (1),77-84頁 2013/07
論文	Structure of the trypanosome cyanide-insensitive alternative oxidase PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110 (12),4580-4585頁 2013/03
論文	3P034 Toward an understanding of lipid-protein interactions, the use of the heavy atom labeled fatty acid analogues(01A. Protein: Structure,Poster) Seibutsu Butsuri 53 (1),S217 2013
論文	The bulky side chain of antillatoxin is important for potent toxicity: rational design of photoresponsive cytotoxins based on SAR studies CHEMICAL COMMUNICATIONS 49 (73),8024-8026頁 2013
論文	Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel CHEMMEDCHEM 7 (10),1770-1773頁 2012/10
論文	16 脂質ラフト形成の分子機構(口頭発表の部) 天然有機化合物討論会講演要旨集 (54),91-96頁 2012/09/01
論文	P-56 ヒト心臓由来脂肪酸結合タンパク質の脂肪酸認識機構研究(ポスター発表の部) 天然有機化合物討論会講演要旨集 (54),621-626頁 2012/09/01
論文	Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134 (34),14011-14018頁 2012/08
論文	Effects of the phosphatidylglycerol head group on the binding of short dermcidin-derived peptides to the phospholipid membrane surface TETRAHEDRON LETTERS 53 (9),1078-1081頁 2012/02
論文	2PT116 Study of the Fatty Acid Binding Mechanism to Human Heart Fatty Acid Binding Protein (FABP3)(The 50th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri 52,S124 2012
論文	Short polyglutamine peptide forms a high-affinity binding site for thioflavin-T at the N-terminus ORGANIC & BIOMOLECULAR CHEMISTRY 10 (30),5787-5790頁 2012
論文	32 ポリセオナミドミミックの設計・全合成・イオンチャネル機能(口頭発表の部) 天然有機化合物討論会講演要旨集 (53),187-192頁 2011/09/02
論文	Synthesis and biological evaluation of triazole analogues of antillatoxin TETRAHEDRON 67 (35),6659-6672頁 2011/09
論文	Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50 (21),4879-4883頁 2011
論文	The effect of sulfur stereochemistry of L-beta,beta-dimethylmethionine S-oxide on the physicochemical properties of truncated polytheonamides TETRAHEDRON LETTERS 51 (35),4644-4647頁 2010/09
論文	ChemInform Abstract: The First F-Ring Modified Ciguatoxin Analogue Showing Significant Toxicity. ChemInform 41 (37),no-no頁 2010/08
論文	Variability in C-3-Plant Cell-Wall Biosynthesis in a High-CO2 Atmosphere by Solid-State NMR Spectroscopy JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132 (18),6335-6341頁 2010/05
論文	Total synthesis of the large non-ribosomal peptide polytheonamide B NATURE CHEMISTRY 2 (4),280-285頁 2010/04
論文	Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66 (3),275-278頁 2010/03
論文	Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 66 (3),304-308頁 2010/03
論文	Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66 (3),304-308頁 2010
論文	The first F-ring modified ciguatoxin analogue showing significant toxicity CHEMICAL COMMUNICATIONS 46 (17),2968-2970頁 2010
論文	The Twisted Side Chain of Antillatoxin is Important for Potent Toxicity: Total Synthesis and Biological Evaluation of Antillatoxin and Analogues ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 49 (2),329-332頁 2010
論文	Crystallization and preliminary X-ray analysis of aspartate transcarbamoylase from the parasitic protist Trypanosoma cruzi ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 65 (9),933-936頁 2009/09
論文	17 巨大ペプチド系天然物ポリセオナミドBの全合成(口頭発表の部) 天然有機化合物討論会講演要旨集 (50),125-130頁 2008/09/01
論文	Vancomycin derivative with damaged D-Ala-D-Ala binding cleft binds to cross-linked peptidoglycan in the cell wall of Staphylococcus aureus BIOCHEMISTRY 47 (12),3822-3831頁 2008/03
論文	Critical Importance of the Nine-Membered F Ring of Ciguatoxin for Potent Bioactivity: Total Synthesis and Biological Evaluation of F-Ring-Modified Analogues ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 47 (45),8611-8614頁 2008
論文	Self-assembled amphotericin B is probably surrounded by ergosterol: Bimolecular interactions as evidenced by solid-state NMR and CD spectra CHEMISTRY-A EUROPEAN JOURNAL 14 (4),1178-1185頁 2008
論文	Dipolar double-quantum filtered rotational-echo double resonance MAGNETIC RESONANCE IN CHEMISTRY 45,S61-S64頁 2007/12
論文	Structure activity relationship of some new secondary metabolites, amphidinols, isolated from marine dinoflagellate, with mode of action studies DRUGS OF THE FUTURE 32,29-30頁 2007/07
論文	Double-quantum filtered rotational-echo double resonance JOURNAL OF MAGNETIC RESONANCE 183 (2),252-258頁 2006/12
論文	Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities Bioorg. Med. Chem. 14 (19),6548-6554頁 2006/11
論文	Membrane interaction of amphotericin B as single-length assembly examined by solid state NMR for uniformly C-13-enriched agent BIOORGANIC & MEDICINAL CHEMISTRY 14 (19),6608-6614頁 2006/10
論文	P-159 STRUCTURE ELUCIDATION OF SOME NEW AMPHIDINOLS AND STRUCTURE ACTIVITY RELATIONSHIPS FOR POLYENE AND POLYHYDROXYL CHAINS International Symposium on the Chemistry of Natural Products 2006,"P-159"頁 2006/07/23
論文	P-380 Amphotericin B-Sterol Covalent Conjugates Forming Molecular Assemblage in Membrane Studied by Solid State NMR International Symposium on the Chemistry of Natural Products 2006,"P-380"頁 2006/07/23
論文	43 生体膜のイオン透過性を増大させる天然物の分子機構 : 高分解能NMRによる脂質二重膜中の立体配座解析(口頭発表の部) 天然有機化合物討論会講演要旨集 (47),223-227頁 2005/09/15
論文	Isolation and structure elucidation of a new amphidinol with a truncated polyhydroxyl chain from Amphidinium klebsii TETRAHEDRON 61 (36),8606-8610頁 2005/09
論文	Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral alpha-helix peptides BIOORGANIC & MEDICINAL CHEMISTRY 13 (17),5099-5103頁 2005/09
論文	Hairpin conformation of amphidinols possibly accounting for potent membrane permeabilizing activities TETRAHEDRON 61 (11),2795-2802頁 2005/03
論文	Dominant formation of a single-length channel by amphotericin B in dimyristoylphosphatidylcholine membrane evidenced by C-13-P-31 rotational echo double resonance BIOCHEMISTRY 44 (2),704-710頁 2005/01
論文	Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1667 (1),91-100頁 2004/11
論文	An amphotericin B-ergosterol covalent conjugate with powerful membrane permeabilizing activity CHEMISTRY & BIOLOGY 11 (5),673-679頁 2004/05
論文	Membrane permeabilizing activity of amphotericin B is affected by chain length of phosphatidylcholine added as minor constituent BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1617 (1-2),109-115頁 2003/10
論文	Amphotericin B-phospholipid covalent conjugates: dependence of membrane-permeabilizing activity on acyl-chain length ORGANIC & BIOMOLECULAR CHEMISTRY 1 (22),3882-3884頁 2003
論文	33 アンフォテリシンB誘導体が生体膜中に形成するチャネル複合体(口頭発表の部) 天然有機化合物討論会講演要旨集 (44),193-198頁 2002/09/01
論文	Cholesterol markedly reduces ion permeability induced by membrane-bound amphotericin B BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1564 (2),429-434頁 2002/08
論文	Amphotericin B dimers with bisamide linkage bearing powerful membrane-permeabilizing activity ORGANIC LETTERS 4 (12),2087-2089頁 2002/06
論文	Amphotericin B covalent dimers forming sterol-dependent ion-permeable membrane channels JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124 (16),4180-4181頁 2002/04
論文	103(P-60) アンフォテリシンB連結分子の構造とイオンチャネル活性(ポスター発表の部) 天然有機化合物討論会講演要旨集 (43),611-616頁 2001/09/01
論文	Acetate labeling patterns of dinoflagellate polyketides, amphidinols 2, 3 and 4 TETRAHEDRON 57 (26),5551-5555頁 2001/06
論文	109(P-34) アンフォテリシンB連結分子の作製と複合体形成(ポスター発表の部) 天然有機化合物討論会講演要旨集 (42),649-654頁 2000/10/01
論文	Absolute configuration of a ceramide with a novel branched-chain fatty acid isolated from the epiphytic dinoflagellate, coolia monotis Bioscience, Biotechnology and Biochemistry 64 (9),1842-1846頁 2000
論文	Absolute configuration of amphidinol 3, the first complete structure determination from amphidinol homologues: Application of a new configuration analysis based on carbon-hydrogen spin-coupling constants [8] Journal of the American Chemical Society 121 (4),870-871頁 1999/02/03
論文	A new ceramide with a novel branched-chain fatty acid isolated from the epiphytic dinoflagellate Coolia monotis Journal of Natural Products 61 (5),685-688頁 1998