研究者総覧 - 花田　礼子

ハナダ　レイコ
花田　礼子

所属大分大学医学部基礎医学・生理学

職種教授

論文
論文	Functional characterization of zebrafish Kcnh2a splice variants reveals distinct gating properties Biochemical and Biophysical Research Communications 834,154446-154446頁 2026/10
論文	Deletion of neurosecretory proteins GL and GM drives dual anti-obesity effects via appetite suppression and enhanced energy expenditure Communications Biology 9 (1),1168-1168頁 2026/06/03
論文	Analysis of the role of the NMU system in memory and emotional behavior. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),215-215頁 2026/05
論文	Comparison of the electrophysiological properties of human and zebrafish KCNH2a channels. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),279-279頁 2026/05
論文	Elucidation of the physiological effects of caffeine on aggressive behavior in zebrafish. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),256-256頁 2026/05
論文	Empagliflozin and β-Hydroxybutyrate attenuate extracellular adenosine release from hepatocytes in zebrafish under high-cholesterol diet. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),297-297頁 2026/05
論文	Evaluation of extracellular ATP/Adenosine dynamics in zebrafish model of acute heart failure. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),288-288頁 2026/05
論文	In vivo analysis of the physiological role of ketone bodies on hepatic extracellular ATP/Ado dynamics in the zebrafish ALD model. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),254-254頁 2026/05
論文	The Effect of Neuromedin U in Chronic Kidney Disease. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),187-187頁 2026/05
論文	The physiological function of NPGL/NPGM system in stress response. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),215-215頁 2026/05
論文	Unraveling cardiac extracellular ATP/Adenosine dynamics in vivo zebrafish model of heart failure. The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),245-245頁 2026/05
論文	Vitamin E Modulates the Hepatocyte Extracellular ATP/Adenosine DAMP System to Attenuate Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD). The Journal of Physiological Sciences (Proceedings of the 103rd Annual Meeting of the Physiological Society of Japan) 76 (1, Supplement),147-147頁 2026/05
論文	Generative AI-Assisted Indication of Anatomical Landmarks to Enhance Safety under Intraoperative Bleeding in Laparoscopic Gastrectomy for Gastric Cancer. Annals of Surgery Open 7 (2),e665-e665頁 2026/04/29
論文	Common dominant-negative spectrum of SLC45A2 mutations in OCA4 defined by endoplasmic reticulum retention. Biochemical and biophysical research communications 811,153578-153578頁 2026/03/06
論文	Genetic deletion of neuromedin U and neuromedin S confers transient reno-protection in adenine-induced chronic kidney disease. Peptides 196,171474-171474頁 2026/02/18
論文	In vivo visualization of cardiac extracellular adenosine dynamics and its pharmacological modulation in zebrafish heart failure models Scientific Reports 16,8220-8220頁 2026/02/11
論文	Vitamin E Modulates Hepatic Extracellular Adenosine Signaling to Attenuate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) International Journal of Molecular Sciences 27 (2),614-614頁 2026/01
論文	A gain-of-function PIK3CD variant, R512W, impairs T cell function through polyamine-dependent metabolic dysregulation Biochemical and Biophysical Research Communications 778,152378-152378頁 2025/09
論文	Behavioral changes induced by VNUT inhibitor in a zebrafish depression model. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),689 2025/08
論文	Elucidating the physiological significance of mastication in depression. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),662 2025/08
論文	Evaluation of Damage Associated Molecular Patterns(DAMPs) in a Zebrafish model of Heart Failure. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),280 2025/08
論文	Ketone bodies improve alcoholic liver disease by reducing extracellular hepatocyte ATP/adenosine levels in Zebrafish. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),397 2025/08
論文	Novel therapeutic strategies to improve metabolic disfunction-associated steatotic liver disease (MASLD) via the hepatocyte extracellular ATP/adenosine (Ado) system. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),294 2025/08
論文	On the role of the NMU system in fear memory. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),607 2025/08
論文	Role of adenosine in the control of aggressive behavior in zebrafish. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),688 2025/08
論文	The physiological function of NPGL/NPGM system in higher brain function. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),246 2025/08
論文	The Role of Hepatic Extracellular ATP and Adenosine Dynamics in a Zebrafish Model of Liver Steatosis. The Journal of Physiological Sciences (Proceedings of the 102st Annual Meeting of The Physiological Society of Japan) 75 (1, Supplement),294 2025/08
論文	Dietary texture-driven masticatory activity and its impact on stress tolerance. Journal of oral biosciences 67 (1),100628-100628頁 2025/02/07
論文	Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy. Orphanet journal of rare diseases 19 (1),219-219頁 2024/05/28
論文	Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology 7 (1),654-654頁 2024/05/28
論文	Pathophysiological role of liver extracellular ATP/ADO in MALFD/MASH using zebrafish model The Journal of Physiological Sciences (Proceedings of the 101st Annual Meeting of The Physiological Society of Japan) 74,28-28頁 2024/05
論文	The analysis of change in subcellular localization of a putative sleep regulator, ARHGEF2 via SIK3. The Journal of Physiological Sciences (Proceedings of the 101st Annual Meeting of The Physiological Society of Japan) 74 (Supplement2) 2024/05
論文	脂肪性肝疾患ゼブラフィッシュにおける細胞外ATP/Ado動態(Extracellular ATP/Ado dynamics in zebrafish with steatotic liver disease) 日本内分泌学会雑誌 100 (1),308-308頁 2024/05
論文	DHCR7 links cholesterol synthesis with neuronal development and axonal integrity. Biochemical and biophysical research communications 712-713,149932-149932頁 2024/04/12
論文	Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease. Scientific reports 14 (1),7813-7813頁 2024/04/03
論文	Behavioral and neurotransmitter changes on antiepileptic drugs treatment in the zebrafish pentylenetetrazol-induced seizure model. Behavioural brain research 464,114920-114920頁 2024/02/23
論文	A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish. Biochemical and biophysical research communications 699,149551-149551頁 2024/01/19
論文	Chemogenetic Activation of Oxytocin Neurons Improves Pain in a Reserpine-induced Fibromyalgia Rat Model. Neuroscience 528,37-53頁 2023/09/15
論文	Behavioral and neurological effects of Vrk1 deficiency in zebrafish. Biochemical and biophysical research communications 675,10-18頁 2023/07/04
論文	Physiological function of NPGL/NPGM system in energy metabolism The Journal of Physiological Sciences 73,11-11頁 2023/03
論文	The central roles of NPGL/NPGM system in energy homeostasis The Journal of Physiological Sciences 72 (Suppl 1),33-33頁 2022/12
論文	Ankle2 deficiency-associated microcephaly and spermatogenesis defects in zebrafish are alleviated by heterozygous deletion of vrk1. Biochemical and biophysical research communications 624,95-101頁 2022/07/31
論文	Vrk2 deficiency elicits aggressive behavior in female zebrafish. Genes to cells : devoted to molecular & cellular mechanisms 27 (4),254-265頁 2022/04
論文	Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity. Biological & pharmaceutical bulletin 45 (8),1172-1179頁 2022
論文	Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10. Biochemical and biophysical research communications 570,60-66頁 2021/09/17
論文	Roles of endogenous NPGL/NPGM system in energy metabolism The Journal of Physiological Sciences 71,24-24頁 2021/08
論文	Neuromedin U, a Key Molecule in Metabolic Disorders. International journal of molecular sciences 22 (8) 2021/04/19
論文	Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish. Scientific reports 11 (1),8392-8392頁 2021/04/16
論文	Corrigendum to "Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish". Biochemical and biophysical research communications 546,200-200頁 2021/03/26
論文	Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Biochemical and biophysical research communications 533 (4),1470-1476頁 2020/12/17
論文	The role of the RANKL/RANK/OPG system in the central nervous systems (CNS). Journal of bone and mineral metabolism 39 (1),64-70頁 2020/09/04
論文	ゼブラフィッシュにてNAFLD/NASHの発症・進展に影響を与えるAPPL2の生理メカニズム(Physiological mechanisms of APPL2 on NAFLD/NASH pathogenesis in zebrafish) 日本内分泌学会雑誌 96 (1),369-369頁 2020/08
論文	Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system Heliyon 6 (5),e03947-e03947頁 2020/05
論文	Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2. Biochemical and biophysical research communications 525 (3),726-732頁 2020/03/03
論文	CLP1 acts as the main RNA kinase in mice. Biochemical and biophysical research communications 2020/02/17
論文	AIF-regulated oxidative phosphorylation supports lung cancer development. Cell research 29 (7),579-591頁 2019/07
論文	CD105 maintains the thermogenic program of beige adipocytes by regulating Smad2 signaling. Molecular and cellular endocrinology 474,184-193頁 2018/10
論文	Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice Peptides 99,134-141頁 2018/01/01
論文	CLP1 links tRNA metabolism to progressive motor-neuron loss NATURE 495 (7442),474-480頁 2013/03
論文	ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation NATURE 487 (7408),477-U89頁 2012/07
論文	[Mechanism of central body temperature regulation by RANKL/RANK]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 139 (6),277-277頁 2012/06
論文	[Central regulation of body temperature by RANKL/RANK pathway]. Clinical calcium 21 (8),1201-1208頁 2011/08
論文	RANKL/RANK-beyond bones JOURNAL OF MOLECULAR MEDICINE-JMM 89 (7),647-656頁 2011/07
論文	Physiology and pathophysiology of the RANKL/RANK system BIOLOGICAL CHEMISTRY 391 (12),1365-1370頁 2010/12
論文	Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer NATURE 468 (7320),98-+頁 2010/11
論文	Central control of fever and female body temperature by RANKL/RANK NATURE 462 (7272),505-509頁 2009/11
論文	Central control of bone remodeling by neuromedin U NATURE MEDICINE 13 (10),1234-1240頁 2007/10
論文	Regulation of gonadotropin secretion and puberty onset by neuromedin U FEBS LETTERS 580 (14),3485-3488頁 2006/06
論文	Ghrelin directly regulates bone formation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20 (5),790-8頁 2005/05
論文	Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway NATURE MEDICINE 10 (10),1067-1073頁 2004/10
論文	Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 323 (2),615-620頁 2004/10
論文	Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity NATURE MEDICINE 10 (7),739-743頁 2004/07