研究者総覧 - 泥谷　直樹

ヒジヤ　ナオキ
泥谷　直樹

所属大分大学医学部基礎医学・分子病理学

職種准教授

論文
論文	The SMYD3-MEK/ERK Axis Contributes to Intestinal Metaplasia and H. pylori-associated Gastric Carcinogenesis. Laboratory investigation; a journal of technical methods and pathology,106137-106137頁 2026/05/20
論文	Histone Deacetylase 10 Inhibitors Suppress Progression of Endometriosis via Activation of Interferon Regulatory Factor 6 and Dachshund Homolog 1. The journal of obstetrics and gynaecology research 52 (5),e70315 2026/05
論文	Annexin A8 drives MEK inhibitor resistance, providing a druggable target for pancreatic ductal adenocarcinoma. Molecular cancer therapeutics 2026/01/29
論文	Establishment of a Novel Organoid Line from Esophageal Squamous Cell Carcinoma with Cytoplasmic Vacuoles: Association of Autolysosome Swelling with Vacuole Formation. Pathobiology : journal of immunopathology, molecular and cellular biology,1-12頁 2025/11/07
論文	IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors (セレブロンの標的タンパク質およびその下流エフェクターの抑制を介したIMiD/CELMoD誘導性成人T細胞白血病/リンパ腫細胞の増殖抑制) Frontiers in Oncology 13 2024/01/24
論文	Characterization of residual cancer by comparison of a pair of organoids established from a patient with esophageal squamous cell carcinoma before and after neoadjuvant chemotherapy Human Cell 37 (2),491-450頁 2024/01/06
論文	Overexpression of VSNL1 enhances cell proliferation in colorectal carcinogenesis Pathobiology : journal of immunopathology, molecular and cellular biology 2023/10/05
論文	Association of immune-related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma Cancer science 2023/09/15
論文	Patient-Derived Ex Vivo Cultures and Endpoint Assays with Surrogate Biomarkers in Functional Testing for Prediction of Therapeutic Response (治療効果予測機能検査における代替バイオマーカーを用いた患者由来の生体外培養とエンドポイントアッセイ) Cancers 15 (16),4104-4104頁 2023/08/15
論文	Efficient Establishment of Bile-Derived Organoids From Patients With Biliary Cancer Laboratory investigation; a journal of technical methods and pathology 103 (6),100105-100105頁 2023/02/07
論文	Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor Cancer science 114 (5),2189-2202頁 2023/01/24
論文	Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids. Laboratory investigation; a journal of technical methods and pathology 102 (12),1355-1366頁 2022/08/03
論文	hsa-miR-199a-3p Inhibits Motility, Invasiveness, and Contractility of Ovarian Endometriotic Stromal Cells Reproductive Sciences 2021/12
論文	Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells. Laboratory investigation; a journal of technical methods and pathology 101 (8),1036-1047頁 2021/08
論文	Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential Pathobiology 88 (5),374-382頁 2021
論文	S6 ribosomal protein phosphorylation is associated with malignancy of intraductal papillary mucinous neoplasm of the pancreas Annals of Gastroenterological Surgery 4 (5),571-579頁 2020/09
論文	DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells Biochemical and Biophysical Research Communications 528 (3),586-593頁 2020/07
論文	A transgenic mouse expressing miR‐210 in proximal tubule cells shows mitochondrial alteration: possible association of miR‐210 with a shift in energy metabolism The Journal of Pathology 251 (1),12-25頁 2020/05
論文	Invasive intraductal papillary mucinous neoplasms of the pancreas: relationships between mural nodules detected on thin-section contrast-enhanced MDCT and invasive components. Abdominal radiology (New York) 44 (9),3139-3147頁 2019/09
論文	【腹部の最新画像情報2019】術前画像診断に苦慮した膵invasive intraductal papillary mucinous carcinomaの1例臨床放射線 64 (7),915-919頁 2019/06
論文	Association of fibrotic remodeling and cytokines/chemokines content in epicardial adipose tissue with atrial myocardial fibrosis in patients with atrial fibrillation. Heart rhythm 15 (11),1717-1727頁 2018/11
論文	Chronic hypoxia‐induced slug promotes invasive behavior of prostate cancer cells by activating expression of ephrin‐B1 Cancer Science 109 (10),3159-3170頁 2018/10
論文	Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan. Genome announcements 6 (25) 2018/06/21
論文	Small pancreatic ductal carcinomas on triple-phase contrast-enhanced computed tomography: enhanced rims and the pathologic correlation Abdominal Radiology 43 (12),1-7頁 2018/05/23
論文	Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas. Cancer science 109 (1),250-258頁 2018/01
論文	Periportal lymphatic system on post-hepatobiliary phase Gd-EOB-DTPA-enhanced MR imaging in normal subjects and patients with chronic hepatitis C ABDOMINAL RADIOLOGY 42 (10),2410-2419頁 2017/10
論文	Overexpression of cannabinoid receptor 1 in esophageal squamous cell carcinoma is correlated with metastasis to lymph nodes and distant organs, and poor prognosis PATHOLOGY INTERNATIONAL 67 (2),83-90頁 2017/02
論文	Periportal low attenuation associated with liver metastasis from colorectal cancer: evaluation using multi-detector-row CT with pathological correlation JAPANESE JOURNAL OF RADIOLOGY 35 (1),10-15頁 2017/01
論文	Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells CANCER SCIENCE 107 (12),1919-1928頁 2016/12
論文	Perirenal lymphatic systems: Evaluation using spectral presaturation with inversion recovery T-2-weighted MR images with 3D volume isotropic turbo spin-echo acquisition at 3.0T JOURNAL OF MAGNETIC RESONANCE IMAGING 44 (4),897-905頁 2016/10
論文	An 80-gene set to predict response to preoperative chemoradiotherapy for rectal cancer by principle component analysis Molecular and Clinical Oncology 4 (5),733-739頁 2016/05
論文	Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma CANCER RESEARCH 76 (9),2612-2625頁 2016/05
論文	Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway JOURNAL OF PATHOLOGY 239 (1),97-108頁 2016/05
論文	Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma CANCER SCIENCE 107 (4),417-423頁 2016/04
論文	Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma CANCER MEDICINE 4 (1),112-124頁 2015/01
論文	Expression of DDX27 contributes to colony-forming ability of gastric cancer cells and correlates with poor prognosis in gastric cancer AMERICAN JOURNAL OF CANCER RESEARCH 5 (10),2998-3014頁 2015
論文	子宮内膜症におけるアポトーシス受容体DR6の発現低下と病態形成への関与 Reproductive Immunology and Biology 29 (1-2),95-95頁 2014/11
論文	Pancreatic neuroendocrine tumor with extensive intraductal invasion of the main pancreatic duct: A case report Journal of the Pancreas 15 (5),497-500頁 2014/09/01
論文	Death receptor 6 is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989) 70 (6),485-496頁 2013/12
論文	CCAAT/enhancer-binding protein α is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis. The Journal of clinical endocrinology and metabolism 98 (9),E1474-82頁 2013/09
論文	MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2. Molecular cancer 12,15-15頁 2013/02/25
論文	Genomic Profiling of Oral Squamous Cell Carcinoma by Array-Based Comparative Genomic Hybridization PLOS ONE 8 (2),e56165 2013/02
論文	Visinin-like protein-1 overexpression is an indicator of lymph node metastasis and poor prognosis in colorectal cancer patients INTERNATIONAL JOURNAL OF CANCER 131 (6),1307-1317頁 2012/09
論文	"Peripancreatic strands appearance" in pancreatic body and tail carcinoma: evaluation by multi-detector CT with pathological correlation ABDOMINAL IMAGING 37 (4),602-608頁 2012/08
論文	Extrahepatic Bile Duct Cancer: Invasion of the Posterior Hepatic Plexuses-Evaluation Using Multidetector CT RADIOLOGY 263 (2),419-428頁 2012/05
論文	Genomic profiling of renal cell carcinoma in patients with end-stage renal disease CANCER SCIENCE 103 (3),569-576頁 2012/03
論文	Intraductal papillary mucinous neoplasms of the pancreas complicated with intraductal hemorrhage, perforation, and fistula formation: CT and MR imaging findings with pathologic correlation ABDOMINAL IMAGING 37 (1),100-109頁 2012/02
論文	Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma BMC CANCER 11,523 2011/12
論文	Genomic Profiling of Submucosal-Invasive Gastric Cancer by Array-Based Comparative Genomic Hybridization PLOS ONE 6 (7),e22313 2011/07
論文	Overexpression of miR-210, a downstream target of HIF1, causes centrosome amplification in renal carcinoma cells. J Pathol 224 (2),280-288頁 2011/06
論文	Overexpression of miR-210, a downstream target of HIF1 alpha, causes centrosome amplification in renal carcinoma cells JOURNAL OF PATHOLOGY 224 (2),280-288頁 2011/06
論文	Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization. The Journal of pathology 221 (1),96-105頁 2010/05
論文	Invasive carcinomas originating from intraductal papillary mucinous neoplasms of the pancreas: conspicuity and primary sites of the solid masses on triple-phase dynamic CT imaging ABDOMINAL IMAGING 35 (2),181-188頁 2010/04
論文	MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer research 70 (6),2339-2349頁 2010/03
論文	Analysis of p53 Mutations and the Expression of p53 and p21^WAF1/CIP1Protein in 15 Cases of Sebaceous Carcinoma of the Eyelid Investigative Opthalmology & Visual Science 2010/01/01
論文	Analysis of p53 mutations and the expression of p53 and p21WAF1/CIP1 protein in 15 cases of sebaceous carcinoma of the eyelid. Investigative ophthalmology & visual science 51 (1),7-11頁 2010/01
論文	Evaluation of rapid urine test for the detection of Helicobacter pylori infection in the Vietnamese population. Digestive diseases and sciences 55 (1),89-93頁 2010/01
論文	Induction of GNE in Myofibers after Muscle Injury Pathobiology 77 (4),191-199頁 2010
論文	Genome-wide microRNA expression profiling in renal cell carcinoma: Significant down-regulation of miR-141 and miR-200c Journal of Pathology 216,418-427頁 2008/12/01
論文	Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas APMIS 116 (12),1097-1106頁 2008/12
論文	Genome-wide microRNA expression profiling in renal cell carcinoma: significant downregulation of miR-141 and miR-200c. J Pathol. 216 (4),418-427頁 2008/12
論文	Genome‐wide analysis of DNA copy number alterations and gene expression in gastric cancer The Journal of Pathology 216 (4),471-482頁 2008/12
論文	Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody. Pathology international 58 (4),218-225頁 2008/04
論文	Phosphorylation status of epidermal growth factor receptor is closely associated with responsiveness to gefitinib in pulmonary adenocarcinoma Human Pathology 39 (3),316-323頁 2008/03
論文	Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury Histochemistry and Cell Biology 129 (1),55-64頁 2008/01
論文	Immunohistochemical diagnosis of the cagA-gene genotype of Helicobacter pylori with anti-East Asian CagA-specific antibody CANCER SCIENCE 98 (4),521-528頁 2007/04
論文	Aortic root subadventitial hematoma Heart and Vessels 22 (2),136-138頁 2007/03
論文	Upregulated expression of cardiac ankyrin–repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis Human Pathology 38 (3),410-419頁 2007/03
論文	ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20 (2),199-207頁 2007/02
論文	Extracellular signal-regulated protein kinase is activated in cervical intraepithelial neoplasms but inactivated in invasive cervical carcinoma. Pathology international 56 (7),368-374頁 2006/07
論文	Roles of CD14 in LPS-induced liver injury and lethality in mice pretreated with Propionibacterium acnes IMMUNOLOGY LETTERS 94 (1-2),47-55頁 2004/06
論文	Expression of splice variants of the human ADAM15 gene and strong interaction between the cytoplasmic domain of one variant and Src family proteins Lck and Hck PATHOBIOLOGY 71 (4),185-192頁 2004
論文	Involvement of CD14 in lipopolysaccharide-induced liver injury in mice pretreated with Propionibacterium acnes PATHOBIOLOGY 71 (5),246-252頁 2004
論文	Pinhole rupture of aortic root aneurysm with severe atherosclerotic change Annals of Thoracic Surgery 77 (3),1075-1077頁 2004
論文	The roles of soluble osteopontin using osteopontin-transgenic mice in vivo: proliferation of CD4+ T lymphocytes and the enhancement of cell-mediated immune responses. Pathobiology : journal of immunopathology, molecular and cellular biology 71 (1),1-11頁 2004
論文	Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 309 (4),779-785頁 2003/10
論文	Expression of murine N-myc by insertion of retrovirus sequences in a murine macrophage cell line (RAW264) PATHOBIOLOGY 70 (4),209-214頁 2002
論文	Mouse soluble CD14 truncated at amino acid 71 in transgenic mice: Preventive effect on endotoxin-mediated toxic shock PATHOBIOLOGY 70 (2),103-114頁 2002
論文	Possible involvement of toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide PATHOBIOLOGY 70 (1),18-25頁 2002
論文	Induction of a novel mechanism of accelerated bacterial clearance by lipopolysaccharide in CD14-deficient and toll-like receptor 4-deficient mice JOURNAL OF IMMUNOLOGY 166 (2),1075-1078頁 2001/01
論文	Transcriptional regulation of the human osteopontin promoter: functional analysis and DNA-protein interactions ONCOGENE 19 (50),5801-5809頁 2000/11
論文	A novel pathway of accelerated bacterial clearance in CD14-deficient and Toll-like receptor 4-deficient mice. JOURNAL OF LEUKOCYTE BIOLOGY,30-30頁 2000
論文	ADAM family proteins in the immune system IMMUNOLOGY TODAY 20 (6),278-284頁 1999/06
論文	CD14 plays no major role in shock induced by Staphylococcus aureus but down-regulates TNF-alpha production JOURNAL OF IMMUNOLOGY 162 (8),4801-4805頁 1999/04
論文	Lipopolysaccharide structure influences the macrophage response via CD14-independent and CD14-dependent pathways CLINICAL INFECTIOUS DISEASES 28 (3),491-496頁 1999/03
論文	Acute pancreatitis induces cytokine production in endotoxin-resistant mice ANNALS OF SURGERY 227 (6),904-910頁 1998/06
論文	Structure of the murine CD156 gene, characterization of its promoter, and chromosomal location JOURNAL OF BIOLOGICAL CHEMISTRY 272 (29),18209-18215頁 1997/07
論文	Evidence for a functional kit receptor in melanoma, breast, and lung carcinoma cells CANCER GENE THERAPY 4 (3),176-182頁 1997/05
論文	Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice IMMUNITY 4 (4),407-414頁 1996/04
論文	EFFECT OF RECOMBINANT OSTEOPONTIN ON ADHESION AND MIGRATION OF P388D1 CELLS OSTEOPONTIN: ROLE IN CELL SIGNALLING AND ADHESION 760,378-380頁 1995
論文	STRUCTURE OF THE OSTEOPONTIN GENE AND ITS PROMOTER OSTEOPONTIN: ROLE IN CELL SIGNALLING AND ADHESION 760,44-58頁 1995
論文	CLONING AND CHARACTERIZATION OF THE HUMAN OSTEOPONTIN GENE AND ITS PROMOTER BIOCHEMICAL JOURNAL 303,255-262頁 1994/10
論文	Stenosis of Right Ventricular Outflow Tract by Myocardial Metastasis Developing after Resection of Lung Cancer Haigan 31 (4),555-559頁 1991