研究者総覧 - 花田　克浩

ハナダ　カツヒロ
花田　克浩

所属大分大学医学部先進医療科学科・先進医療科学

職種講師

論文
論文	Analysis of DNA double-strand breaks induced by DNA damaging agents in trophoblast organoids. Methods (San Diego, Calif.) 255,27-36頁 2026/08/09
論文	Mitotic abnormality induced by evodiamine, a tryptamine indole alkaloid. Toxicology and applied pharmacology,117813-117813頁 2026/04/02
論文	Alpha-1-microglobulin profile in patients on maintenance hemodialysis and its removal by blood purification. Renal failure 47 (1),2512403-2512403頁 2025/12
論文	Fibulin-4 is required for the mechanical stability of tendons Cell and Tissue Research 2025/11/13
論文	A new approach to assessing reproductive toxicity using placental organoids. Toxicology Letters 411 (Supplement),S347-S348頁 2025/09
論文	Investigation of the accumulation of double-strand DNA breaks in mouse organs by DNA damaging agents using pulsed-field gel electrophoresis Toxicology Letters 441 (Supplement),S157-S157頁 2025/09
論文	Helicobacter pylori base-excision restriction enzyme in stomach carcinogenesis. PNAS nexus 4 (8),pgaf244 2025/08
論文	Analysis of accumulation of DNA double-strand breaks in mouse tissues by pulsed-field gel electrophoresis Toxicology and Applied Pharmacology 497,117278-117278頁 2025/04
論文	Timosaponin AIII Disrupts Cell–Extracellular Matrix Interactions through the Inhibition of Endocytic Pathways Biological and Pharmaceutical Bulletin 47 (10),1648-1656頁 2024/10/11
論文	Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice FEBS Open Bio 2024/04
論文	Investigation of the inhibition of bacteria and endotoxin influx by back filtration through dialyzer membranes. Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 2023/02/10
論文	Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition Communications Biology 5 (1) 2022/09/16
論文	The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants Scientific Reports 11 (1),7718-7718頁 2021/12
論文	薬剤開発研究の新規手法としての循環式三次元組織培養システム化学工業 72 (5),293-299頁 2021/05
論文	Timosaponin Aiii Disrupts Morphological Plasticity and Migration of Breast Adenocarcinoma Through Inhibition of Integrin Internalisation 2021/03/15
論文	Timosaponin AIII disturbs morphological plasticity and migration by suppressing membrane dynamics. Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (0),2-P2頁 2021
論文	Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome Science Advances 6 (51),eabd7197-eabd7197頁 2020/12
論文	Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction. Cardiovascular research 117 (4),1103-1117頁 2020/07/09
論文	Analysis of Chromosomal DNA Fragmentation in Apoptosis by Pulsed-Field Gel Electrophoresis. Methods in molecular biology (Clifton, N.J.) 2119,89-99頁 2020
論文	Detection of Bleomycin-Induced DNA Double-Strand Breaks in Escherichia coli by Pulsed-Field Gel Electrophoresis Using a Rotating Gel Electrophoresis System Methods in Molecular Biology 2119,155-163頁 2020
論文	Detection of DNA Double-Strand Breaks by Pulsed-Field Gel Electrophoresis of Circular Bacterial Chromosomes Methods in Molecular Biology,145-154頁 2020
論文	Introduction and Perspectives of DNA Electrophoresis Methods in Molecular Biology,1-13頁 2020
論文	Investigation on Hard-Tissue Compatibility of TiN Surface Formed by Atmospheric-Pressure-Plasma Nitriding Plasma and Fusion Research 13,1306120-1306120頁 2018/10/23
論文	Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumor microenvironment Genes to Cells 23 (6),466-479頁 2018/06/01
論文	Genome instability syndromes caused by impaired DNA repair and aberrant DNA damage responses Cell Biology and Toxicology 34,1-14頁 2018/04/05
論文	Aggregatibacter actinomycetemcomitans infection causes DNA double-strand breaks in host cells. Genes to cells : devoted to molecular & cellular mechanisms 23 (4),264-273頁 2018/04
論文	Expression and purification of recombinant fibulins in mammalian cells Methods in Cell Biology 143,1-39頁 2018
論文	Therapeutic effect of lyophilized Kefir-fermented milk on constipation among people with mental and physical disabilities. Jpn J Nur Sci 15,218-225頁 2018
論文	Detection of DNA double-strand breaks by pulsed-field gel electrophoresis GENES TO CELLS 22 (1),84-93頁 2017/01
論文	Mechanisms of gene targeting in higher eukaryotes CELLULAR AND MOLECULAR LIFE SCIENCES 73 (3),523-533頁 2016/02
論文	2重鎖切断修復機構としての相同組換え. 生物工学会誌 94 (7),420-424頁 2016
論文	Mechanisms of interstrand DNA crosslink repair and human disorders Genes and Environment 38 (1),9 2016
論文	Multiple malignant changes and recurrent infections in the skin associated with long-term exposure to ultraviolet light and topical psoralen plus ultraviolet A therapy JOURNAL OF DERMATOLOGY 42 (5),536-537頁 2015/05
論文	FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51 NATURE COMMUNICATIONS 6,5931 2015/01
論文	Prophylactic effects of Kefir-fermented milk on constipation among mentally and physically handicapped persons. J Prob Health 3,126 2015
論文	Genetic battle between Helicobacter pylori and humans. The mechanism underlying homologous recombination in bacteria, which can infect human cells MICROBES AND INFECTION 16 (10),833-839頁 2014/10
論文	Helicobacter pylori Infection Introduces DNA Double-Strand Breaks in Host Cells INFECTION AND IMMUNITY 82 (10),4182-4189頁 2014/10
論文	Helicobacter pylori and the molecular pathogenesis of intestinal-type gastric carcinoma EXPERT REVIEW OF ANTICANCER THERAPY 14 (8),947-954頁 2014/08
論文	FBH1 Helicase Disrupts RAD51 Filaments in Vitro and Modulates Homologous Recombination in Mammalian Cells JOURNAL OF BIOLOGICAL CHEMISTRY 288 (47),34168-34180頁 2013/11
論文	FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress NATURE COMMUNICATIONS 4,1423 2013/01
論文	The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination DNA REPAIR 10 (11),1095-1105頁 2011/11
論文	The relationship between Helicobacter pylori infection and Alzheimer's disease in Japan JOURNAL OF NEUROLOGY 258 (8),1460-1463頁 2011/08
論文	Efficient Homofermentative L-(+)-Lactic Acid Production from Xylose by a Novel Lactic Acid Bacterium, Enterococcus mundtii QU 25 APPLIED AND ENVIRONMENTAL MICROBIOLOGY 77 (5),1892-1895頁 2011/03
論文	UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways JOURNAL OF CELL SCIENCE 124 (3),435-446頁 2011/02
論文	BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells ONCOGENE 29 (33),4705-4714頁 2010/08
論文	Efficient conversion of lactic acid to butanol with pH-stat continuous lactic acid and glucose feeding method by Clostridium saccharoperbutylacetonicum APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 87 (3),1177-1185頁 2010/07
論文	Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes GUT PATHOGENS 2,13 2010
論文	XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair MOLECULAR AND CELLULAR BIOLOGY 29 (24),6427-6437頁 2009/12
論文	The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks NATURE STRUCTURAL & MOLECULAR BIOLOGY 14 (11),1096-1104頁 2007/11
論文	Roles of the DNA binding proteins H-NS and StpA in homologous recombination and repair of bleomycin-induced damage in Escherichia coli GENES & GENETIC SYSTEMS 82 (5),433-439頁 2007/10
論文	Molecular genetics of RecQ helicase disorders CELLULAR AND MOLECULAR LIFE SCIENCES 64 (17),2306-2322頁 2007/09
論文	Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice CIRCULATION RESEARCH 100 (5),738-746頁 2007/03
論文	The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks EMBO JOURNAL 25 (20),4921-4932頁 2006/10
論文	Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks EMBO JOURNAL 24 (22),3952-3962頁 2005/11
論文	Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination EMBO JOURNAL 23 (17),3548-3558頁 2004/09
論文	Involvement of mammalian Mus81 in genome integrity and tumor suppression SCIENCE 304 (5678),1822-1826頁 2004/06
論文	Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells EMBO JOURNAL 22 (22),6137-6147頁 2003/11
論文	Roles of recJ, RecO, and RecR in RecET-mediated illegitimate recombination in Escherichia coli JOURNAL OF BACTERIOLOGY 184 (17),4715-4721頁 2002/09
論文	Role of DnaB helicase in UV-induced illegitimate recombination in Escherichia coli JOURNAL OF BACTERIOLOGY 183 (17),4964-4969頁 2001/09
論文	Role of DNA ligase in the illegitimate recombination that generates lambda bio-transducing phages in Escherichia coli GENETICS 158 (1),29-39頁 2001/05
論文	Suppression of gamma ray-induced illegitimate recombination in Escherichia coli by the DNA binding protein H-NS MOLECULAR GENETICS AND GENOMICS 265 (2),242-248頁 2001/04
論文	DNAの切断再結合による非相同組換え．蛋白質核酸酵素 46 (8),1063-1972頁 2001
論文	Suppression of gamma ray-induced illegitimate recombination in Escherichia coli by the DNA-binding protein H-NS Molecular and General Genetics 265 (2),242-248頁 2001
論文	UvrA and UvrB suppress illegitimate recombination: Synergistic action with RecQ helicase PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97 (11),5989-5994頁 2000/05
論文	Control of genetic stability in Escherichia coli: the SbcB 3 '-5 ' exonuclease suppresses illegitimate recombination promoted by the RecE 5 '-3 ' exonuclease GENES TO CELLS 5 (2),101-109頁 2000/02
論文	Illegitimate recombination induced by overproduction of DnaB helicase in Escherichia coli JOURNAL OF BACTERIOLOGY 181 (15),4549-4553頁 1999/08
論文	Escherichia coli MutM suppresses illegitimate recombination induced by oxidative stress GENETICS 151 (2),439-446頁 1999/02
論文	DNA２本鎖切断とエンドジョイニング複合体．蛋白質核酸酵素 44 (12),1838-1844頁 1999
論文	The retrotransposon RTip1 is integrated into a novel type of minisatellite, MiniSip1, in the genome of the common morning glory and carries another new type of minisatellite, MiniSip2 THEORETICAL AND APPLIED GENETICS 95 (7),1049-1056頁 1997/11
論文	RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94 (8),3860-3865頁 1997/04