研究者総覧 - 一二三　恵美

ヒフミ　エミ
一二三　恵美

所属大分大学研究マネジメント機構研究推進センター

職種教授

論文
論文	Structural and biochemical differences between non-catalytic and catalytic antibodies mAbs 17 (1) 2025/05/12
論文	Experimental and Computational Studies on Domain-Swapped Structure Stabilization of an Antibody Light Chain by Disulfide Bond Introduction. Journal of medicinal chemistry 67 (24),22313-22321頁 2024/12/26
論文	Enzymatization of mouse monoclonal antibodies to the corresponding catalytic antibodies. Scientific reports 14 (1),12184-12184頁 2024/05/28
論文	Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping. Nature communications 14 (1),7807-7807頁 2023/12/08
論文	Direct conversion of a general antibody to its catalytic antibody and corresponding applications —Importance and role of Pro95 in CDR-3— Proceedings of the Japan Academy, Series B 99 (6),155-172頁 2023/06/19
論文	Cononsolvency of poly(carboxybetaine methacrylate) in water–ethanol mixed solvents Polymer Journal 2023/04/25
論文	Enhanced Singlet Oxygen Generation via Near‐Infrared Photo‐Activated Upconversion: Application to Amyloid Fibril Degradation ChemPhotoChem 2023/04/22
論文	Obtaining Highly Active Catalytic Antibodies Capable of Enzymatically Cleaving Antigens International Journal of Molecular Sciences 23 (22),14351-14351頁 2022/11/18
論文	A new catalytic site functioning in antigen cleavage by H34 catalytic antibody light chain Scientific Reports 12 (1) 2022/11/10
論文	Modulation of Double Zwitterionic Block Copolymer Aggregates by Zwitterion-Specific Interactions Langmuir 37 (50),14760-14766頁 2021/12/21
論文	Finding and characterizing a catalytic antibody light chain, H34, capable of degrading the PD-1 molecule RSC Chemical Biology 2 (1),220-229頁 2021
論文	A new algorithm to convert a normal antibody into the corresponding catalytic antibody. Science advances 6 (13),eaay6441 2020/03
論文	Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles Photochemical & Photobiological Sciences 19 (1),29-33頁 2020/01
論文	New technologies to introduce a catalytic function into antibodies: A unique human catalytic antibody light chain showing degradation of β-amyloid molecule along with the peptidase activity FASEB BioAdvances 1 (2),93-104頁 2019/01/29
論文	Role of the constant region domain in the structural diversity of human antibody light chains FASEB JOURNAL 31 (4),1668-1677頁 2017/04
論文	Detection of influenza virus by a biosensor based on the method combining electrochemiluminescence on binary SAMs modified Au electrode with an immunoliposome encapsulating Ru (II) complex ANALYTICAL AND BIOANALYTICAL CHEMISTRY 408 (22),5963-5971頁 2016/09
論文	A novel method of preparing the monoform structure of catalytic antibody light chain FASEB JOURNAL 30 (2),895-908頁 2016/02
論文	Biochemical features and antiviral activity of a monomeric catalytic antibody light-chain 23D4 against influenza A virus FASEB JOURNAL 29 (6),2347-2358頁 2015/06
論文	Biochemical Features of a Catalytic Antibody Light Chain, 22F6, Prepared from Human Lymphocytes JOURNAL OF BIOLOGICAL CHEMISTRY 288 (27),19558-19568頁 2013/07
論文	Highly efficient method of preparing human catalytic antibody light chains and their biological characteristics FASEB JOURNAL 26 (4),1607-1615頁 2012/04
論文	Catalytic and Biochemical Features of a Monoclonal Antibody Heavy Chain, JN1-2, Raised against a Synthetic Peptide with a Hemagglutinin Molecule of Influenza Virus JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133 (38),15015-15024頁 2011/09
論文	Catalytic digestion of human tumor necrosis factor-alpha by antibody heavy chain FEBS JOURNAL 277 (18),3823-3832頁 2010/09
論文	Characteristic features of InfA-15 monoclonal antibody recognizing H1, H3, and H5 subtypes of hemagglutinin of influenza virus A type JOURNAL OF BIOSCIENCE AND BIOENGINEERING 109 (6),598-608頁 2010/06
論文	Rapid detection of BSA protein by electrochemiluminescence sensor combining an immunoliposome which encapsulates a Ru complex ELECTROCHEMISTRY 76 (8),579-582頁 2008/08
論文	Therapeutic effects of molecularly designed antigen UREB138 for mice infected with Helicobacter pylori BIOTECHNOLOGY AND BIOENGINEERING 100 (4),634-643頁 2008/07
論文	Attomole detection of hemagglutinin molecule of influenza virus by combining an electrochemiluminescence sensor with an immunoliposome that encapsulates a Ru complex ANALYTICAL CHEMISTRY 80 (11),4020-4025頁 2008/06
論文	Catalytic features and eradication ability of antibody light-chain UA15-L against Helicobacter pylori JOURNAL OF BIOLOGICAL CHEMISTRY 283 (2),899-907頁 2008/01
論文	Highly sensitive detection of influenza virus hemagglutinin by electrochemiluminescence using immunoliposome ECS Transactions 16 (11),115-121頁 2008
論文	Effects of vaccination by a recombinant antigen ureB138 (a segment of the beta-subunit of urease) against Helicobacter pylori infection JOURNAL OF MEDICAL MICROBIOLOGY 56 (6),847-853頁 2007/06
論文	Pathogenicity of catalytic antibodies: catalytic activity of Bence Jones proteins from myeloma patients with renal impairment can elicit cytotoxic effects BIOLOGICAL CHEMISTRY 387 (5),543-548頁 2006/05
論文	[Super catalytic antibodies (antigenase) capable of destroying H. pylori urease]. Nihon rinsho. Japanese journal of clinical medicine 64 (2),286-292頁 2006/02
論文	A catalytic antibody heavy chain HpU-2 degrading its epitope peptide and H-pylori urease IMMUNOLOGY LETTERS 103 (1),68-74頁 2006/02
論文	Specific degradation of H-pylori urease by a catalytic antibody light chain FEBS JOURNAL 272 (17),4497-4505頁 2005/09
論文	Investigation of active form of catalytic antibody light chain 41S-2-L IMMUNOLOGY LETTERS 96 (1),63-71頁 2005/01
論文	Application of electrochemiluminescence sensor to a rapid method of estimating activity of enzyme in hydrolysis of peptides ELECTROANALYSIS 16 (15),1262-1265頁 2004/08
論文	Recombinant antigen from Helicobacter pylori urease as vaccine against H-pylori-associated disease BIOTECHNOLOGY AND BIOENGINEERING 86 (7),737-746頁 2004/06
論文	Epitope mapping and features of the epitope for monoclonal antibodies inhibiting enzymatic activity of heficobacter pylori urease BIOTECHNOLOGY AND BIOENGINEERING 86 (4),434-444頁 2004/05
論文	Catalytic antibody light chain capable of cleaving a chemokine receptor CCR-5 peptide with a high reaction rate constant BIOTECHNOLOGY AND BIOENGINEERING 86 (2),217-225頁 2004/04
論文	Improvement of catalytic antibody activity by protease processing BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 315 (3),612-616頁 2004/03
論文	Super catalytic antibody and antigenase JOURNAL OF BIOSCIENCE AND BIOENGINEERING 97 (3),143-152頁 2004/03
論文	"Super catalytic antibodies" cleaving targeted molecules of viruses and bacterium 2004 INTERNATIONAL CONFERENCE ON MEMS, NANO AND SMART SYSTEMS, PROCEEDINGS,616-616頁 2004
論文	Antigenase: Antigen decomposing enzyme "Super catalytic antibody" 2004 INTERNATIONAL CONFERENCE ON MEMS, NANO AND SMART SYSTEMS, PROCEEDINGS,90-90頁 2004
論文	Catalytic features of monoclonal antibody i41SL1-2 subunits BIOTECHNOLOGY AND BIOENGINEERING 84 (4),485-493頁 2003/11
論文	Endopeptidase character of monoclonal antibody i41-7 subunits IMMUNOLOGY LETTERS 86 (3),249-257頁 2003/05
論文	Targeted destruction of the HIV-1 coat protein gp41 by a catalytic antibody light chain JOURNAL OF IMMUNOLOGICAL METHODS 269 (1-2),283-298頁 2002/11
論文	Elimination of ingredients effect to improve the detection anti HIV-1 p24 antibody in human serum using SPR apparatus ANALYTICAL SCIENCES 18 (8),863-867頁 2002/08
論文	Presence of catalytic activity of the antibody light chain raised against complementarity determining region peptide of super catalytic antibody BIOLOGICAL SYSTEMS ENGINEERING 830,200-208頁 2002
論文	Simultaneous detection of two antigens by surface plasmon resonance sensor ELECTROCHEMISTRY 69 (12),976-979頁 2001/12
論文	Preparation and immunological features of syngeneic monoclonal anti-idiotypic antibody using complementary determining region (CDR) peptide as the immunogen LETTERS IN PEPTIDE SCIENCE 7 (5),299-310頁 2001
論文	Removal of catalytic activity by EDTA from antibody light chain BIOMETALS 13 (4),289-294頁 2000/12
論文	Analysis of the antigen recognition sites of anti-methamphetamine monoclonal antibodies (II): Unique feature of MA-3 antibody JOURNAL OF BIOSCIENCE AND BIOENGINEERING 89 (5),492-494頁 2000/05
論文	Design of an artificial molecular catalyst showing peptidase activity to the conserved sequence of HIV-1 envelope gp41 JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL 155 (1-2),209-218頁 2000/04
論文	Catalytic activity of antibody light chain to gp41: A consideration of refolding in relation to activation mechanism CHEMICAL IMMUNOLOGY 77,18-32頁 2000/01
論文	How and why 41S-2 antibody subunits acquire the ability to catalyze decomposition of the conserved sequence of gp41 of HIV-1 APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 83 (1-3),209-219頁 2000/01
論文	Preparation and immunological features of syngeneic monoclonal anti-idiotypic antibody using complementary determining region (CDR) peptide as the immunogen International Journal of Peptide Research and Therapeutics 7 (5),299-310頁 2000
論文	Super catalytic antibody [I]: Decomposition of targeted protein by its antibody light chain JOURNAL OF BIOSCIENCE AND BIOENGINEERING 88 (3),323-327頁 1999/09
論文	Immunochemical features of complementarity determining region (CDR) peptide in anti hemin monoclonal antibody JOURNAL OF PEPTIDE SCIENCE 5 (1),24-31頁 1999/01
論文	Amplification of SPR responses for the immunoreaction using anti HIV gp41 antibody by the method of molecular accumulation IEEJ Transactions on Sensors and Micromachines 119 (11),522-527頁 1999
論文	Immunological features and inhibitory effects on enzymatic activity of monoclonal antibodies against Helicobacter pylori urease JOURNAL OF FERMENTATION AND BIOENGINEERING 86 (3),271-276頁 1998
論文	Analysis of the antigen recognition sites of anti-methamphetamine monoclonal antibodies .1. JOURNAL OF FERMENTATION AND BIOENGINEERING 83 (4),333-340頁 1997
論文	Immunochemical detection of methamphetamine using polymer-protected ultrafine platinum particles JOURNAL OF FERMENTATION AND BIOENGINEERING 82 (4),417-419頁 1996
論文	Sensing of the antibody against AIDS virus protein gp41 and the influence of serum using surface plasmon resonance DENKI KAGAKU 63 (12),1160-1166頁 1995/12
論文	An approach for an immunoaffinity AIDS sensor using the conservative region of the HIV envelope protein (gp41) and its monoclonal antibody Biosensors and Bioelectronics 10 (5),477-483頁 1995
論文	Effects of synthetic water-soluble derivatives of protoporphyrin and its metal complex on tumor cell growth and their superoxide dismutase- and peroxidase-like activities Porphyrins 4 (2),89-94頁 1995
論文	PRODUCTION AND IMMUNOCHEMICAL FEATURE FOR SYNGENEIC MONOCLONAL ANTIIDIOTYPIC ANTIBODIES TO MORPHINE BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 67 (11),3044-3047頁 1994/11
論文	APPLICATION OF POLYMER-PROTECTED ULTRAFINE PLATINUM PARTICLES TO THE IMMUNOLOGICAL DETECTION OF HUMAN SERUM-ALBUMIN ANALYTICAL BIOCHEMISTRY 218 (2),259-264頁 1994/05
論文	PRODUCTION AND IMMUNOLOGICAL CHARACTERIZATION FOR ANTI HEMIN MONOCLONAL-ANTIBODY CHEMISTRY LETTERS 11 (11),1923-1926頁 1993/11
論文	CHARACTERIZATION OF MORPHINE-SPECIFIC MONOCLONAL-ANTIBODIES SHOWING MINIMAL CROSS-REACTIVITY WITH CODEINE JOURNAL OF IMMUNOLOGICAL METHODS 157 (1-2),143-148頁 1993/01
論文	COMPARISON OF MONOCLONAL ANTIBODY-BASED ENZYME-LINKED-IMMUNOSORBENT-ASSAY WITH THIN-LAYER CHROMATOGRAPHY AND LIQUID-CHROMATOGRAPHY FOR AFLATOXIN-B1 DETERMINATION IN NATURALLY CONTAMINATED CORN AND MIXED FEED JOURNAL OF AOAC INTERNATIONAL 75 (2),307-312頁 1992/03
論文	Comparison of a monoclonal antibody based ELISA with TLC and HPLC for aflatoxin B1 analysis of naturally contaminated corn and mixed-feed. J. Assoc.Off.Anal.Chem. 75 (2),307-312頁 1992
論文	直接ELISA法によるアフラトキシンB₁の検出マイコトキシン 1987 (26),31-35頁 1987
論文	ワンステップ法ELISAによるオクラトキシンAおよびT-2トキシンの検出法マイコトキシン 1986 (24),25-29頁 1986